STRINGSTRING
grpE protein (Cyanothece sp. PCC7424) - STRING interaction network
"grpE" - Protein GrpE in Cyanothece sp. PCC7424
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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grpEProtein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- dependent [...] (286 aa)    
Predicted Functional Partners:
ACK72550.1
Chaperone protein DnaK; Acts as a chaperone (723 aa)
 
 
  0.932
ACK71362.1
Chaperone protein DnaK; Acts as a chaperone (638 aa)
 
 
  0.918
ACK70040.1
Chaperone protein DnaK; Acts as a chaperone (729 aa)
 
 
  0.911
dnaJ
Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] (375 aa)
 
 
  0.908
ACK70222.1
60 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (542 aa)
 
 
  0.857
ACK71254.1
60 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (556 aa)
 
 
  0.852
ACK68641.1
PFAM- Heat shock protein 70; KEGG- mar-MAE_16770 heat shock protein 70 (531 aa)
 
 
  0.847
groS
10 kDa chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (103 aa)
   
   
  0.831
hrcA
Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (360 aa)
   
   
  0.814
ACK71257.1
Chaperone protein HtpG; Molecular chaperone. Has ATPase activity (669 aa)
     
   
  0.799
Your Current Organism:
Cyanothece sp. PCC7424
NCBI taxonomy Id: 65393
Other names: C. sp. PCC 7424, Cyanothece sp. PCC 7424, Cyanothece sp. PCC7424, Synechococcus sp. ATCC 29155 (no longer available), Synechococcus sp. PCC 7424
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