STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
trpEAnthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (508 aa)    
Predicted Functional Partners:
ACK71123.1
TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; KEGG: amr:AM1_1430 anthranilate synthase component II.
 0.999
trpD
Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).
 
 0.998
trpD-2
Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).
 
 0.998
trpC
PFAM: Indole-3-glycerol phosphate synthase; KEGG: ana:all0413 indole-3-glycerol phosphate synthase; Belongs to the TrpC family.
 
 0.992
trpC-2
PFAM: Indole-3-glycerol phosphate synthase; KEGG: mar:MAE_45030 indole-3-glycerol phosphate synthase; Belongs to the TrpC family.
 
 0.992
ACK70697.1
Anthranilate synthase; TIGRFAM: glutamine amidotransferase of anthranilate synthase; anthranilate synthase; PFAM: glutamine amidotransferase class-I; Chorismate binding-like; KEGG: ava:Ava_4890 anthranilate synthase.
  
0.974
trpA-2
Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
 
  
 0.971
trpA
Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
 
  
 0.970
ACK72945.1
TIGRFAM: para-aminobenzoate synthase, subunit I; glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; Anthranilate synthase component I domain protein; Chorismate binding-like; KEGG: ana:alr3443 p-aminobenzoic acid synthase.
 
0.960
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
 
 
 0.947
Your Current Organism:
Gloeothece citriformis
NCBI taxonomy Id: 65393
Other names: Cyanothece sp. PCC 7424, G. citriformis PCC 7424, Gloeothece citriformis PCC 7424, Synechococcus sp. ATCC 29155 (no longer available), Synechococcus sp. PCC 7424
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