| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AMQ41512.1 | AMQ42953.1 | AMS64_03425 | AMS64_11515 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Folylpolyglutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the folylpolyglutamate synthase family. | 0.670 |
| AMQ41512.1 | AMQ44818.1 | AMS64_03425 | AMS64_21915 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.905 |
| AMQ41512.1 | folB | AMS64_03425 | AMS64_03430 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.998 |
| AMQ41512.1 | folE | AMS64_03425 | AMS64_13390 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | GTP cyclohydrolase; Involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.904 |
| AMQ41512.1 | folK | AMS64_03425 | AMS64_04825 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Catalyzes the formation of 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine and ATP; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.923 |
| AMQ41512.1 | folP | AMS64_03425 | AMS64_18810 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.996 |
| AMQ41512.1 | pabB | AMS64_03425 | AMS64_09955 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Para-aminobenzoate synthase component 1; catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and L-glutamine; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.508 |
| AMQ41512.1 | plsY | AMS64_03425 | AMS64_03435 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Glycerol-3-phosphate acyltransferase; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. | 0.592 |
| AMQ41512.1 | rdgB | AMS64_03425 | AMS64_19880 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Nucleoside-triphosphate diphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.574 |
| AMQ41512.1 | ribD | AMS64_03425 | AMS64_18920 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.555 |
| AMQ42953.1 | AMQ41512.1 | AMS64_11515 | AMS64_03425 | Folylpolyglutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the folylpolyglutamate synthase family. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.670 |
| AMQ42953.1 | AMQ44818.1 | AMS64_11515 | AMS64_21915 | Folylpolyglutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the folylpolyglutamate synthase family. | 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.578 |
| AMQ42953.1 | folB | AMS64_11515 | AMS64_03430 | Folylpolyglutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the folylpolyglutamate synthase family. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.765 |
| AMQ42953.1 | folE | AMS64_11515 | AMS64_13390 | Folylpolyglutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the folylpolyglutamate synthase family. | GTP cyclohydrolase; Involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.793 |
| AMQ42953.1 | folK | AMS64_11515 | AMS64_04825 | Folylpolyglutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the folylpolyglutamate synthase family. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Catalyzes the formation of 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine and ATP; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.773 |
| AMQ42953.1 | folP | AMS64_11515 | AMS64_18810 | Folylpolyglutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the folylpolyglutamate synthase family. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.998 |
| AMQ42953.1 | rdgB | AMS64_11515 | AMS64_19880 | Folylpolyglutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the folylpolyglutamate synthase family. | Nucleoside-triphosphate diphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.577 |
| AMQ42953.1 | ribD | AMS64_11515 | AMS64_18920 | Folylpolyglutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the folylpolyglutamate synthase family. | 5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.545 |
| AMQ44818.1 | AMQ41512.1 | AMS64_21915 | AMS64_03425 | 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.905 |
| AMQ44818.1 | AMQ42953.1 | AMS64_21915 | AMS64_11515 | 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Folylpolyglutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the folylpolyglutamate synthase family. | 0.578 |