STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
A0A0D3F9B3DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1524 aa)    
Predicted Functional Partners:
A0A0D3EXJ7
Structural maintenance of chromosomes protein.
   
 
 0.871
A0A0D3GWG5
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]
   
 
 0.871
A0A0D3EM96
UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.792
A0A0D3G9D8
Structural maintenance of chromosomes protein.
   
 
 0.791
A0A0D3EPT1
Uncharacterized protein.
   
 
 0.785
A0A0D3H3Q0
AAA_23 domain-containing protein.
   
 
 0.778
A0A0D3FMZ8
Protein kinase domain-containing protein.
   
  
 0.730
A0A0D3FBS7
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
  
 
 0.724
A0A0D3ENV7
Ubiquitin-like domain-containing protein.
    
 0.712
A0A0D3EWB9
Ubiquitin-like domain-containing protein.
    
 0.712
Your Current Organism:
Oryza barthii
NCBI taxonomy Id: 65489
Other names: African wild rice, O. barthii, Oryza barthii A.Chev., Oryza breviligulata, Oryza breviligulata A.Chev. & Roehr.
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.