SEQ91204.1 protein (Lentzea albida) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

SEQ91204.1

Methyltransferase domain-containing protein. (199 aa)

Predicted Functional Partners:

SEQ91180.1

0.992

SEQ91154.1

0.959

SEQ91227.1

0.954

SEQ91131.1

0.926

SEQ91108.1

0.841

SEQ91250.1

0.834

SEP92631.1

0.598

SER72972.1

0.416

Your Current Organism:

Lentzea albida

NCBI taxonomy Id: 65499
Other names: Asiosporangium albidum, DSM 44437, IFO 16102, JCM 10670, L. albida, Lentzea albida Labeda et al. 2001, NBRC 16102, NRRL B-24073, Saccharothrix aerocolonigenes subsp. staurosporea, Streptomyces stauroporeus, Streptomyces staurosporeus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SEP92631.1	SEQ91108.1	SAMN04488000_101688	SAMN04488000_10561	Signal transduction histidine kinase.	dTDP-L-rhamnose 4-epimerase.	0.436
SEP92631.1	SEQ91131.1	SAMN04488000_101688	SAMN04488000_10562	Signal transduction histidine kinase.	Hypothetical protein.	0.554
SEP92631.1	SEQ91154.1	SAMN04488000_101688	SAMN04488000_10563	Signal transduction histidine kinase.	Glycosyl transferase family 2.	0.520
SEP92631.1	SEQ91180.1	SAMN04488000_101688	SAMN04488000_10564	Signal transduction histidine kinase.	Hypothetical protein.	0.512
SEP92631.1	SEQ91204.1	SAMN04488000_101688	SAMN04488000_10565	Signal transduction histidine kinase.	Methyltransferase domain-containing protein.	0.598
SEQ91108.1	SEP92631.1	SAMN04488000_10561	SAMN04488000_101688	dTDP-L-rhamnose 4-epimerase.	Signal transduction histidine kinase.	0.436
SEQ91108.1	SEQ91131.1	SAMN04488000_10561	SAMN04488000_10562	dTDP-L-rhamnose 4-epimerase.	Hypothetical protein.	0.912
SEQ91108.1	SEQ91154.1	SAMN04488000_10561	SAMN04488000_10563	dTDP-L-rhamnose 4-epimerase.	Glycosyl transferase family 2.	0.990
SEQ91108.1	SEQ91180.1	SAMN04488000_10561	SAMN04488000_10564	dTDP-L-rhamnose 4-epimerase.	Hypothetical protein.	0.918
SEQ91108.1	SEQ91204.1	SAMN04488000_10561	SAMN04488000_10565	dTDP-L-rhamnose 4-epimerase.	Methyltransferase domain-containing protein.	0.841
SEQ91108.1	SEQ91227.1	SAMN04488000_10561	SAMN04488000_10566	dTDP-L-rhamnose 4-epimerase.	Oxidoreductase molybdopterin binding domain-containing protein.	0.806
SEQ91131.1	SEP92631.1	SAMN04488000_10562	SAMN04488000_101688	Hypothetical protein.	Signal transduction histidine kinase.	0.554
SEQ91131.1	SEQ91108.1	SAMN04488000_10562	SAMN04488000_10561	Hypothetical protein.	dTDP-L-rhamnose 4-epimerase.	0.912
SEQ91131.1	SEQ91154.1	SAMN04488000_10562	SAMN04488000_10563	Hypothetical protein.	Glycosyl transferase family 2.	0.951
SEQ91131.1	SEQ91180.1	SAMN04488000_10562	SAMN04488000_10564	Hypothetical protein.	Hypothetical protein.	0.959
SEQ91131.1	SEQ91204.1	SAMN04488000_10562	SAMN04488000_10565	Hypothetical protein.	Methyltransferase domain-containing protein.	0.926
SEQ91131.1	SEQ91227.1	SAMN04488000_10562	SAMN04488000_10566	Hypothetical protein.	Oxidoreductase molybdopterin binding domain-containing protein.	0.904
SEQ91131.1	SEQ91250.1	SAMN04488000_10562	SAMN04488000_10567	Hypothetical protein.	Hypothetical protein.	0.676
SEQ91154.1	SEP92631.1	SAMN04488000_10563	SAMN04488000_101688	Glycosyl transferase family 2.	Signal transduction histidine kinase.	0.520
SEQ91154.1	SEQ91108.1	SAMN04488000_10563	SAMN04488000_10561	Glycosyl transferase family 2.	dTDP-L-rhamnose 4-epimerase.	0.990

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Network Stats

number of nodes:

6

number of edges:

8

average node degree:

2.67

avg. local clustering coefficient:

0.828

expected number of edges:

5

PPI enrichment p-value:

0.141

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006091

Generation of precursor metabolites and energy

5 of 119

1.28

0.94

0.0043

GO:0019336

Phenol-containing compound catabolic process

2 of 4

2.35

0.87

0.0250

GO:0009060

Aerobic respiration

3 of 30

1.65

0.8

0.0250

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004775

succinate-CoA ligase (ADP-forming) activity

2 of 2

2.65

1.09

0.0104

GO:0051537

2 iron, 2 sulfur cluster binding

2 of 11

1.91

0.75

0.0376

GO:0009055

Electron transfer activity

3 of 68

1.3

0.64

0.0376

GO:0016491

Oxidoreductase activity

7 of 466

0.83

0.57

0.0104

GO:0003824

Catalytic activity

11 of 2418

0.31

0.24

0.0376

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005886

Plasma membrane

8 of 558

0.81

0.7

0.00040

GO:0016020

Membrane

9 of 1581

0.41

0.28

0.0398

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1032

Tricarboxylic acid cycle, and Butanoate metabolism

6 of 11

2.39

4.72

3.00e-10

CL:1034

CoA-ligase, and Fumarate reductase flavoprotein C-term

5 of 5

2.65

4.52

2.54e-09

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00020

Citrate cycle (TCA cycle)

7 of 23

2.14

4.95

5.65e-12

map00650

Butanoate metabolism

5 of 19

2.07

3.4

4.85e-08

map00190

Oxidative phosphorylation

6 of 77

1.55

2.3

1.98e-07

map01200

Carbon metabolism

7 of 109

1.46

2.23

4.85e-08

map01120

Microbial metabolism in diverse environments

9 of 335

1.08

1.37

5.06e-08

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0042709

succinate-CoA ligase complex

2 of 2

2.65

1.15

0.0080

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0816

Tricarboxylic acid cycle

2 of 8

2.05

0.75

0.0404

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00549

CoA-ligase

2 of 2

2.65

0.98

0.0169

PF01557

Fumarylacetoacetate (FAA) hydrolase family

2 of 4

2.35

0.91

0.0211

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR016102

Succinyl-CoA synthetase-like

2 of 2

2.65

0.76

0.0420

IPR005811

ATP-citrate lyase/succinyl-CoA ligase

2 of 2

2.65

0.76

0.0420

IPR036663

Fumarylacetoacetase-like, C-terminal domain superfamily

2 of 4

2.35

0.75

0.0420

IPR011234

Fumarylacetoacetase-like, C-terminal

2 of 4

2.35

0.75

0.0420

IPR036188

FAD/NAD(P)-binding domain superfamily

3 of 43

1.5

0.67

0.0420

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