STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ilvAL-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (411 aa)    
Predicted Functional Partners:
SES35187.1
Acetolactate synthase, small subunit.
  
 
 0.933
SES35175.1
Acetolactate synthase, large subunit.
 
 0.868
SES23595.1
Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family.
 
 0.848
SER58599.1
Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family.
 
 0.843
SER91573.1
Homoserine dehydrogenase.
  
 
 0.839
SES14799.1
Branched-chain amino acid aminotransferase.
  
 
 0.839
SER56047.1
Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 0.830
SES13930.1
Acetolactate synthase, large subunit.
 
 0.824
SEQ60066.1
Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family.
  
 0.818
SER91550.1
Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.
 
 
0.818
Your Current Organism:
Lentzea albida
NCBI taxonomy Id: 65499
Other names: Asiosporangium albidum, DSM 44437, IFO 16102, JCM 10670, L. albida, Lentzea albida Labeda et al. 2001, NBRC 16102, NRRL B-24073, Saccharothrix aerocolonigenes subsp. staurosporea, Streptomyces stauroporeus, Streptomyces staurosporeus
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.