Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ZPR_0863hydroxymethylglutaryl-CoA lyase-like protein. (287 aa)    
Predicted Functional Partners:
ZPR_0093
succinyl-CoA:3-ketoacid-coenzyme A transferase subunit A.
 
 
 0.947
ZPR_0095
succinyl-CoA:3-ketoacid-coenzyme A transferase subunit B.
  
 
 0.936
ZPR_2468
3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.934
ZPR_2596
acetoacetyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.934
ZPR_3056
acyl-CoA carboxylase carboxyl transferase subunit beta.
 
 0.843
ZPR_3845
Class I citrate synthase; Belongs to the citrate synthase family.
  
 
 0.841
sucC
succinyl-CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
   
 0.840
sucD
succinyl-CoA ligase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
 
 0.833
ZPR_0632
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex.
    
 0.820
ZPR_1235
Lipoamide acyltransferase component of 2-oxoacid dehydrogenase complex.
    
 0.820
Your Current Organism:
Zunongwangia profunda
NCBI taxonomy Id: 655815
Other names: Z. profunda SM-A87, Zunongwangia profunda SM-A87, Zunongwangia profunda str. SM-A87, Zunongwangia profunda strain SM-A87
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