| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ZPR_0046 | ZPR_1114 | ZPR_0046 | ZPR_1114 | Phosphoribosylamine--glycine ligase. | Formyl transferase. | 0.921 |
| ZPR_0046 | folD | ZPR_0046 | ZPR_3835 | Phosphoribosylamine--glycine ligase. | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.932 |
| ZPR_0046 | gcvT | ZPR_0046 | ZPR_2588 | Phosphoribosylamine--glycine ligase. | Glycine cleavage system aminomethyltransferase T; The glycine cleavage system catalyzes the degradation of glycine. | 0.446 |
| ZPR_0046 | glyA | ZPR_0046 | ZPR_1219 | Phosphoribosylamine--glycine ligase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.787 |
| ZPR_0046 | purH | ZPR_0046 | ZPR_0662 | Phosphoribosylamine--glycine ligase. | Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.982 |
| ZPR_0046 | purL | ZPR_0046 | ZPR_2473 | Phosphoribosylamine--glycine ligase. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.996 |
| ZPR_0046 | purN | ZPR_0046 | ZPR_0277 | Phosphoribosylamine--glycine ligase. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.999 |
| ZPR_0180 | ZPR_1114 | ZPR_0180 | ZPR_1114 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Formyl transferase. | 0.909 |
| ZPR_0180 | folD | ZPR_0180 | ZPR_3835 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.934 |
| ZPR_0180 | purN | ZPR_0180 | ZPR_0277 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.928 |
| ZPR_1114 | ZPR_0046 | ZPR_1114 | ZPR_0046 | Formyl transferase. | Phosphoribosylamine--glycine ligase. | 0.921 |
| ZPR_1114 | ZPR_0180 | ZPR_1114 | ZPR_0180 | Formyl transferase. | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | 0.909 |
| ZPR_1114 | ZPR_3674 | ZPR_1114 | ZPR_3674 | Formyl transferase. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.913 |
| ZPR_1114 | fmt | ZPR_1114 | ZPR_2525 | Formyl transferase. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.912 |
| ZPR_1114 | folD | ZPR_1114 | ZPR_3835 | Formyl transferase. | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.960 |
| ZPR_1114 | gcvT | ZPR_1114 | ZPR_2588 | Formyl transferase. | Glycine cleavage system aminomethyltransferase T; The glycine cleavage system catalyzes the degradation of glycine. | 0.916 |
| ZPR_1114 | glyA | ZPR_1114 | ZPR_1219 | Formyl transferase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.912 |
| ZPR_1114 | purH | ZPR_1114 | ZPR_0662 | Formyl transferase. | Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.914 |
| ZPR_1114 | purL | ZPR_1114 | ZPR_2473 | Formyl transferase. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.930 |
| ZPR_1114 | purN | ZPR_1114 | ZPR_0277 | Formyl transferase. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.920 |