MAC_00055 protein (Metarhizium acridum) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Cooccurrence

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[Homology]

Score

MAC_00055

Uncharacterized protein. (111 aa)

Predicted Functional Partners:

MAC_04992

0.697

MAC_07916

0.667

MAC_06519

0.598

MAC_08766

0.584

MAC_07114

0.543

MAC_06198

0.529

MAC_04163

0.494

MAC_04755

0.494

MAC_05320

0.494

MAC_08998

0.494

Your Current Organism:

Metarhizium acridum

NCBI taxonomy Id: 655827
Other names: M. acridum CQMa 102, Metarhizium acridum CQMa 102, Metarhizium anisopliae var. acridum CQMa 102

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MAC_00055	MAC_04163	E9DRY2	E9E2R5	Uncharacterized protein.	Homocitrate synthase.	0.494
MAC_00055	MAC_04755	E9DRY2	E9E4F7	Uncharacterized protein.	Homocitrate synthase.	0.494
MAC_00055	MAC_04992	E9DRY2	E9E5B6	Uncharacterized protein.	Multifunctional tryptophan biosynthesis protein; Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.	0.697
MAC_00055	MAC_05320	E9DRY2	E9E622	Uncharacterized protein.	Uncharacterized protein.	0.494
MAC_00055	MAC_06198	E9DRY2	E9E8P0	Uncharacterized protein.	Histidine biosynthesis trifunctional protein.	0.529
MAC_00055	MAC_06519	E9DRY2	E9E9H1	Uncharacterized protein.	Acetolactate synthase small subunit.	0.598
MAC_00055	MAC_07114	E9DRY2	E9EB66	Uncharacterized protein.	2-isopropylmalate synthase.	0.543
MAC_00055	MAC_07916	E9DRY2	E9EDG8	Uncharacterized protein.	3-isopropylmalate dehydratase.	0.667
MAC_00055	MAC_08766	E9DRY2	E9EFW8	Uncharacterized protein.	Tryptophan synthase.	0.584
MAC_00055	MAC_08998	E9DRY2	E9EGK0	Uncharacterized protein.	Uncharacterized protein.	0.494
MAC_04163	MAC_00055	E9E2R5	E9DRY2	Homocitrate synthase.	Uncharacterized protein.	0.494
MAC_04163	MAC_04755	E9E2R5	E9E4F7	Homocitrate synthase.	Homocitrate synthase.	0.901
MAC_04163	MAC_04992	E9E2R5	E9E5B6	Homocitrate synthase.	Multifunctional tryptophan biosynthesis protein; Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.	0.696
MAC_04163	MAC_06198	E9E2R5	E9E8P0	Homocitrate synthase.	Histidine biosynthesis trifunctional protein.	0.694
MAC_04163	MAC_06519	E9E2R5	E9E9H1	Homocitrate synthase.	Acetolactate synthase small subunit.	0.577
MAC_04163	MAC_07114	E9E2R5	E9EB66	Homocitrate synthase.	2-isopropylmalate synthase.	0.903
MAC_04163	MAC_07916	E9E2R5	E9EDG8	Homocitrate synthase.	3-isopropylmalate dehydratase.	0.790
MAC_04163	MAC_08766	E9E2R5	E9EFW8	Homocitrate synthase.	Tryptophan synthase.	0.688
MAC_04755	MAC_00055	E9E4F7	E9DRY2	Homocitrate synthase.	Uncharacterized protein.	0.494
MAC_04755	MAC_04163	E9E4F7	E9E2R5	Homocitrate synthase.	Homocitrate synthase.	0.901

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

51

average node degree:

9.27

avg. local clustering coefficient:

0.941

expected number of edges:

11

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0033693

Neurofilament bundle assembly

3 of 3

3.26

2.54

2.61e-05

GO:0045109

Intermediate filament organization

4 of 54

2.13

2.09

7.83e-05

GO:0060052

Neurofilament cytoskeleton organization

2 of 5

2.87

1.14

0.0088

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005200

Structural constituent of cytoskeleton

4 of 75

1.99

1.83

0.00021

GO:0099184

Structural constituent of postsynaptic intermediate filament cytoskeleton

2 of 2

3.26

1.46

0.0024

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0099160

Postsynaptic intermediate filament cytoskeleton

4 of 4

3.26

4.56

5.12e-09

GO:0005883

Neurofilament

4 of 6

3.09

4.43

7.68e-09

GO:0099513

Polymeric cytoskeletal fiber

5 of 586

1.2

0.95

0.0022

GO:0098685

Schaffer collateral - CA1 synapse

2 of 49

1.87

0.7

0.0474

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:35237613

(2021) Neurofilament Light Regulates Axon Caliber, Synaptic Activity, and Organelle Trafficking in Cultured Human Motor Neurons.

4 of 14

2.72

2.75

8.35e-06

PMID:37070078

(2023) The altered expression of cytoskeletal and synaptic remodeling proteins during epilepsy.

3 of 6

2.96

1.95

0.00029

PMID:34511133

(2021) Sequencing of neurofilament genes identified NEFH Ser787Arg as a novel risk variant of sporadic amyotrophic lateral sclerosis in Chinese subjects.

3 of 7

2.9

1.95

0.00029

PMID:17854500

(2007) Molecular evolution of type VI intermediate filament proteins.

3 of 8

2.84

1.94

0.00029

PMID:21278408

(2011) In vivo monitoring of neuronal loss in traumatic brain injury: a microdialysis study.

3 of 14

2.59

1.65

0.00094

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:21376

Mixed, incl. Kinesin complex, and Postsynaptic intermediate filament cytoskeleton

4 of 29

2.4

2.65

8.69e-06

CL:38839

Mixed, incl. Cadherin-like, and Protein kinase A signaling

2 of 6

2.79

0.98

0.0170

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0099160

Postsynaptic intermediate filament cytoskeleton

3 of 3

3.26

2.96

4.39e-06

GOCC:0045111

Intermediate filament cytoskeleton

4 of 53

2.14

2.47

1.13e-05

GOCC:0005856

Cytoskeleton

6 of 997

1.04

0.82

0.0025

GOCC:0045202

Synapse

4 of 419

1.24

0.72

0.0203

GOCC:0043232

Intracellular non-membrane-bounded organelle

7 of 2612

0.69

0.41

0.0380

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0403

Intermediate filament

4 of 58

2.1

2.46

1.07e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04732

Intermediate filament head (DNA binding) region

3 of 7

2.9

2.46

3.30e-05

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01391

Intermediate filament protein

4 of 56

2.12

2.36

1.84e-05

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