MAC_02341 protein (Metarhizium acridum) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

MAC_02341

Uncharacterized protein. (404 aa)

Predicted Functional Partners:

MAC_01141

0.950

MAC_06098

0.566

MAC_04249

0.444

MAC_01873

0.426

MAC_03740

0.426

MAC_07462

0.426

MAC_05955

0.416

MAC_03208

0.401

Your Current Organism:

Metarhizium acridum

NCBI taxonomy Id: 655827
Other names: M. acridum CQMa 102, Metarhizium acridum CQMa 102, Metarhizium anisopliae var. acridum CQMa 102

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MAC_01141	MAC_02341	E9DU43	E9DXJ3	Nucleoporin nsp1.	Uncharacterized protein.	0.950
MAC_01141	MAC_04249	E9DU43	E9E301	Nucleoporin nsp1.	Elongation factor 3.	0.511
MAC_01141	MAC_05955	E9DU43	E9E7V7	Nucleoporin nsp1.	RNA export mediator Gle1.	0.991
MAC_01141	MAC_06098	E9DU43	E9E8A0	Nucleoporin nsp1.	Elongation factor 3.	0.666
MAC_01873	MAC_02341	E9DW75	E9DXJ3	40S ribosomal protein S8.	Uncharacterized protein.	0.426
MAC_01873	MAC_03208	E9DW75	E9E010	40S ribosomal protein S8.	40S ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family.	0.993
MAC_01873	MAC_04249	E9DW75	E9E301	40S ribosomal protein S8.	Elongation factor 3.	0.991
MAC_01873	MAC_06098	E9DW75	E9E8A0	40S ribosomal protein S8.	Elongation factor 3.	0.991
MAC_02341	MAC_01141	E9DXJ3	E9DU43	Uncharacterized protein.	Nucleoporin nsp1.	0.950
MAC_02341	MAC_01873	E9DXJ3	E9DW75	Uncharacterized protein.	40S ribosomal protein S8.	0.426
MAC_02341	MAC_03208	E9DXJ3	E9E010	Uncharacterized protein.	40S ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family.	0.401
MAC_02341	MAC_03740	E9DXJ3	E9E1J2	Uncharacterized protein.	40S ribosomal protein S22; Belongs to the universal ribosomal protein uS8 family.	0.426
MAC_02341	MAC_04249	E9DXJ3	E9E301	Uncharacterized protein.	Elongation factor 3.	0.444
MAC_02341	MAC_05955	E9DXJ3	E9E7V7	Uncharacterized protein.	RNA export mediator Gle1.	0.416
MAC_02341	MAC_06098	E9DXJ3	E9E8A0	Uncharacterized protein.	Elongation factor 3.	0.566
MAC_02341	MAC_07462	E9DXJ3	E9EC53	Uncharacterized protein.	Histone chaperone; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly.	0.426
MAC_03208	MAC_01873	E9E010	E9DW75	40S ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family.	40S ribosomal protein S8.	0.993
MAC_03208	MAC_02341	E9E010	E9DXJ3	40S ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family.	Uncharacterized protein.	0.401
MAC_03208	MAC_03740	E9E010	E9E1J2	40S ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family.	40S ribosomal protein S22; Belongs to the universal ribosomal protein uS8 family.	0.999
MAC_03208	MAC_04249	E9E010	E9E301	40S ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family.	Elongation factor 3.	0.994

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

40

average node degree:

7.27

avg. local clustering coefficient:

0.872

expected number of edges:

11

PPI enrichment p-value:

2.39e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006352

DNA-templated transcription, initiation

10 of 32

2.27

7.67

7.96e-19

GO:0006366

Transcription by RNA polymerase II

9 of 38

2.15

6.23

9.52e-16

GO:0006367

Transcription initiation from RNA polymerase II promoter

7 of 19

2.34

5.75

7.08e-13

GO:0070897

Transcription preinitiation complex assembly

6 of 14

2.41

5.14

3.62e-11

GO:0051123

RNA polymerase II preinitiation complex assembly

5 of 9

2.52

4.55

1.35e-09

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046982

Protein heterodimerization activity

6 of 22

2.21

4.18

1.59e-09

GO:0016251

RNA polymerase II general transcription initiation factor activity

3 of 8

2.35

1.96

0.00020

GO:0005515

Protein binding

7 of 401

1.02

0.95

0.00023

GO:0017025

TBP-class protein binding

2 of 10

2.08

0.82

0.0295

GO:0003713

Transcription coactivator activity

2 of 12

2.0

0.81

0.0304

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005669

Transcription factor TFIID complex

8 of 12

2.6

7.85

1.30e-16

GO:0090575

RNA polymerase II transcription regulator complex

9 of 33

2.21

6.73

1.30e-16

GO:0016591

RNA polymerase II, holoenzyme

9 of 36

2.18

6.57

1.37e-16

GO:0070461

SAGA-type complex

4 of 6

2.6

3.98

2.72e-08

GO:0000124

SAGA complex

3 of 3

2.78

3.1

1.84e-06

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3593

Transcription factor TFIID complex

10 of 13

2.66

10.55

1.44e-22

CL:3591

Basal transcription factors

11 of 28

2.37

9.47

6.40e-23

CL:3598

Transcription factor TFIID complex, and TBP domain superfamily

8 of 8

2.78

8.87

3.92e-18

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

gsl03022

Basal transcription factors

9 of 25

2.33

7.65

4.93e-18

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-76042

RNA Polymerase II Transcription Initiation And Promoter Clearance

11 of 38

2.24

8.42

8.34e-22

MAP-75953

RNA Polymerase II Transcription Initiation

11 of 38

2.24

8.42

8.34e-22

MAP-73779

RNA Polymerase II Transcription Pre-Initiation And Promoter Opening

11 of 38

2.24

8.42

8.34e-22

MAP-73776

RNA Polymerase II Promoter Escape

11 of 38

2.24

8.42

8.34e-22

MAP-674695

RNA Polymerase II Pre-transcription Events

11 of 53

2.1

7.4

4.26e-21

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005654

Nucleoplasm

8 of 96

1.7

3.28

2.82e-10

GOCC:0016591

RNA polymerase II, holoenzyme

4 of 23

2.02

2.54

4.95e-06

GOCC:0031981

Nuclear lumen

9 of 212

1.41

2.34

7.17e-10

GOCC:1990234

Transferase complex

8 of 230

1.32

1.92

3.36e-08

GOCC:0000124

SAGA complex

2 of 4

2.48

1.54

0.0014

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0396

Initiation factor

10 of 59

2.01

6.07

1.81e-17

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR009072

Histone-fold

6 of 24

2.18

3.89

5.84e-09

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (32%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2025

Credits

Access

Info

About