MAC_04062 protein (Metarhizium acridum) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

MAC_04062

P47 protein. (419 aa)

Predicted Functional Partners:

MAC_02555

0.990

MAC_04323

0.990

MAC_06708

0.987

MAC_00293

0.978

MAC_00132

0.977

MAC_00754

0.962

MAC_05765

0.960

MAC_04944

0.958

MAC_07478

0.942

MAC_00530

0.937

Your Current Organism:

Metarhizium acridum

NCBI taxonomy Id: 655827
Other names: M. acridum CQMa 102, Metarhizium acridum CQMa 102, Metarhizium anisopliae var. acridum CQMa 102

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MAC_00132	MAC_00293	E9DQW3	E9DRC4	OTU-like cysteine protease, putative.	Phospholipase A-2-activating protein.	0.982
MAC_00132	MAC_00530	E9DQW3	E9DSD2	OTU-like cysteine protease, putative.	UBX domain protein, putative.	0.566
MAC_00132	MAC_02555	E9DQW3	E9DY57	OTU-like cysteine protease, putative.	Cell division control protein Cdc48; Belongs to the AAA ATPase family.	0.929
MAC_00132	MAC_04062	E9DQW3	E9E2G4	OTU-like cysteine protease, putative.	P47 protein.	0.977
MAC_00132	MAC_04323	E9DQW3	E9E375	OTU-like cysteine protease, putative.	ATP-dependent Zn protease.	0.929
MAC_00132	MAC_05765	E9DQW3	E9E7B7	OTU-like cysteine protease, putative.	Putative ubiquitin fusion degradation protein 2.	0.974
MAC_00132	MAC_06708	E9DQW3	E9EA10	OTU-like cysteine protease, putative.	Proteasome-activating nucleotidase.	0.897
MAC_00293	MAC_00132	E9DRC4	E9DQW3	Phospholipase A-2-activating protein.	OTU-like cysteine protease, putative.	0.982
MAC_00293	MAC_00530	E9DRC4	E9DSD2	Phospholipase A-2-activating protein.	UBX domain protein, putative.	0.650
MAC_00293	MAC_00754	E9DRC4	E9DTB6	Phospholipase A-2-activating protein.	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	0.516
MAC_00293	MAC_02555	E9DRC4	E9DY57	Phospholipase A-2-activating protein.	Cell division control protein Cdc48; Belongs to the AAA ATPase family.	0.879
MAC_00293	MAC_04062	E9DRC4	E9E2G4	Phospholipase A-2-activating protein.	P47 protein.	0.978
MAC_00293	MAC_04323	E9DRC4	E9E375	Phospholipase A-2-activating protein.	ATP-dependent Zn protease.	0.879
MAC_00293	MAC_04944	E9DRC4	E9E4Z6	Phospholipase A-2-activating protein.	UBA/TS-N domain containing protein.	0.649
MAC_00293	MAC_05765	E9DRC4	E9E7B7	Phospholipase A-2-activating protein.	Putative ubiquitin fusion degradation protein 2.	0.713
MAC_00293	MAC_06708	E9DRC4	E9EA10	Phospholipase A-2-activating protein.	Proteasome-activating nucleotidase.	0.801
MAC_00293	MAC_07478	E9DRC4	E9EC80	Phospholipase A-2-activating protein.	UBX domain protein (Ubx5), putative.	0.501
MAC_00530	MAC_00132	E9DSD2	E9DQW3	UBX domain protein, putative.	OTU-like cysteine protease, putative.	0.566
MAC_00530	MAC_00293	E9DSD2	E9DRC4	UBX domain protein, putative.	Phospholipase A-2-activating protein.	0.650
MAC_00530	MAC_02555	E9DSD2	E9DY57	UBX domain protein, putative.	Cell division control protein Cdc48; Belongs to the AAA ATPase family.	0.751

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

14

average node degree:

2.55

avg. local clustering coefficient:

0.917

expected number of edges:

10

PPI enrichment p-value:

0.166

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006418

tRNA aminoacylation for protein translation

8 of 22

1.79

3.57

2.24e-10

GO:0006520

Cellular amino acid metabolic process

9 of 93

1.22

1.68

3.30e-08

GO:0044271

Cellular nitrogen compound biosynthetic process

10 of 246

0.84

0.86

1.63e-06

GO:1901566

Organonitrogen compound biosynthetic process

10 of 266

0.81

2.34e-06

GO:0044281

Small molecule metabolic process

10 of 291

0.77

0.75

4.92e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004812

aminoacyl-tRNA ligase activity

8 of 23

1.77

3.56

1.35e-10

GO:0016874

Ligase activity

10 of 77

1.34

2.24

1.35e-10

GO:0002161

aminoacyl-tRNA editing activity

3 of 6

1.93

1.7

0.00035

GO:0000049

tRNA binding

4 of 26

1.42

1.33

0.00041

GO:0016884

Carbon-nitrogen ligase activity, with glutamine as amido-N-donor

2 of 8

1.63

0.78

0.0275

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

10 of 623

0.44

0.32

0.0119

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:342

Aminoacyl-tRNA synthetase, class Ia, anticodon-binding

5 of 5

2.23

3.4

1.26e-07

CL:339

Aminoacyl-tRNA synthetase

6 of 11

1.97

3.28

3.91e-08

CL:66

Translation, and Chaperone

7 of 158

0.88

0.73

0.00092

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

phar00970

Aminoacyl-tRNA biosynthesis

6 of 18

1.75

2.84

6.08e-08

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0030

Aminoacyl-tRNA synthetase

8 of 21

1.81

3.91

1.42e-11

KW-0436

Ligase

10 of 56

1.48

2.88

2.39e-12

KW-0648

Protein biosynthesis

8 of 37

1.57

2.85

4.65e-10

KW-0067

ATP-binding

10 of 185

0.96

1.13

4.58e-08

KW-0963

Cytoplasm

8 of 179

0.88

0.86

2.78e-05

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF08264

Anticodon-binding domain of tRNA ligase

3 of 4

2.11

1.48

0.0014

PF00133

tRNA synthetases class I (I, L, M and V)

2 of 2

2.23

0.86

0.0258

PF09334

tRNA synthetases class I (M)

2 of 4

1.93

0.73

0.0427

PF01588

Putative tRNA binding domain

2 of 4

1.93

0.73

0.0427

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR009080

Aminoacyl-tRNA synthetase, class Ia, anticodon-binding

4 of 6

2.06

2.16

4.35e-05

IPR014729

Rossmann-like alpha/beta/alpha sandwich fold

6 of 29

1.55

1.94

7.60e-06

IPR002300

Aminoacyl-tRNA synthetase, class Ia

3 of 4

2.11

1.53

0.0011

IPR001412

Aminoacyl-tRNA synthetase, class I, conserved site

3 of 5

2.01

1.46

0.0014

IPR006195

Aminoacyl-tRNA synthetase, class II

3 of 9

1.75

1.17

0.0042

(more ...)

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