MAC_06501 protein (Metarhizium acridum) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

MAC_06501

Uncharacterized protein. (181 aa)

Predicted Functional Partners:

MAC_00684

0.523

MAC_01292

0.483

MAC_02072

0.481

MAC_03595

0.479

MAC_02989

0.478

MAC_08351

0.477

MAC_09483

0.477

MAC_05347

0.473

MAC_00346

0.461

MAC_05318

0.460

Your Current Organism:

Metarhizium acridum

NCBI taxonomy Id: 655827
Other names: M. acridum CQMa 102, Metarhizium acridum CQMa 102, Metarhizium anisopliae var. acridum CQMa 102

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MAC_00346	MAC_02072	E9DRH7	E9DWS4	Uncharacterized protein.	Putative anaphase control protein cut9.	0.999
MAC_00346	MAC_03595	E9DRH7	E9E147	Uncharacterized protein.	Putative anaphase promoting complex subunit 10.	0.999
MAC_00346	MAC_05318	E9DRH7	E9E620	Uncharacterized protein.	Anaphase-promoting complex subunit ApcB, putative; Belongs to the cullin family.	0.999
MAC_00346	MAC_05347	E9DRH7	E9E649	Uncharacterized protein.	Anaphase-promoting complex protein.	0.999
MAC_00346	MAC_06501	E9DRH7	E9E9F3	Uncharacterized protein.	Uncharacterized protein.	0.461
MAC_00346	MAC_08351	E9DRH7	E9EEQ3	Uncharacterized protein.	Anaphase-promoting complex component Cut20/Apc4, putative.	0.999
MAC_00346	MAC_09483	E9DRH7	E9EHY5	Uncharacterized protein.	20S cyclosome subunit (APC1/BimE), putative.	0.999
MAC_00684	MAC_06501	E9DST6	E9E9F3	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Uncharacterized protein.	0.523
MAC_01292	MAC_02989	E9DUJ4	E9DZE1	Pol II transcription elongation factor subunit Cdc73, putative.	Uncharacterized protein.	0.999
MAC_01292	MAC_06501	E9DUJ4	E9E9F3	Pol II transcription elongation factor subunit Cdc73, putative.	Uncharacterized protein.	0.483
MAC_02072	MAC_00346	E9DWS4	E9DRH7	Putative anaphase control protein cut9.	Uncharacterized protein.	0.999
MAC_02072	MAC_03595	E9DWS4	E9E147	Putative anaphase control protein cut9.	Putative anaphase promoting complex subunit 10.	0.999
MAC_02072	MAC_05318	E9DWS4	E9E620	Putative anaphase control protein cut9.	Anaphase-promoting complex subunit ApcB, putative; Belongs to the cullin family.	0.999
MAC_02072	MAC_05347	E9DWS4	E9E649	Putative anaphase control protein cut9.	Anaphase-promoting complex protein.	0.999
MAC_02072	MAC_06501	E9DWS4	E9E9F3	Putative anaphase control protein cut9.	Uncharacterized protein.	0.481
MAC_02072	MAC_08351	E9DWS4	E9EEQ3	Putative anaphase control protein cut9.	Anaphase-promoting complex component Cut20/Apc4, putative.	0.999
MAC_02072	MAC_09483	E9DWS4	E9EHY5	Putative anaphase control protein cut9.	20S cyclosome subunit (APC1/BimE), putative.	0.999
MAC_02989	MAC_01292	E9DZE1	E9DUJ4	Uncharacterized protein.	Pol II transcription elongation factor subunit Cdc73, putative.	0.999
MAC_02989	MAC_06501	E9DZE1	E9E9F3	Uncharacterized protein.	Uncharacterized protein.	0.478
MAC_03595	MAC_00346	E9E147	E9DRH7	Putative anaphase promoting complex subunit 10.	Uncharacterized protein.	0.999

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

28

PPI enrichment p-value:

1.32e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006351

Transcription, DNA-templated

7 of 25

2.0

3.95

5.53e-10

GO:0006352

DNA-templated transcription, initiation

3 of 15

1.85

1.41

0.0014

GO:0019438

Aromatic compound biosynthetic process

8 of 270

1.02

1.06

1.90e-05

GO:0018130

Heterocycle biosynthetic process

8 of 294

0.98

0.99

3.13e-05

GO:1901362

Organic cyclic compound biosynthetic process

8 of 305

0.97

0.96

3.63e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003899

DNA-directed 5-3 RNA polymerase activity

4 of 6

2.37

2.73

5.59e-06

GO:0016987

Sigma factor activity

3 of 15

1.85

1.33

0.0021

GO:0003677

DNA binding

7 of 307

0.91

0.75

0.0010

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000428

DNA-directed RNA polymerase complex

4 of 9

2.2

2.71

3.94e-06

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:37075846

(2023) Transcription regulation by CarD in mycobacteria is guided by basal promoter kinetics.

4 of 6

2.37

2.55

1.31e-05

PMID:38741736

(2024) Function of the RNA-targeting class 2 type VI CRISPR Cas system of Rhodobacter capsulatus.

3 of 3

2.55

2.0

0.00020

PMID:30200857

(2018) Transcriptional Responses to ppGpp and DksA.

4 of 14

2.0

1.99

9.46e-05

PMID:34254822

(2021) Promoter Architecture Differences among Alphaproteobacteria and Other Bacterial Taxa.

3 of 5

2.33

1.84

0.00034

PMID:24516534

(2014) Transcriptional profiling of nitrogen fixation and the role of NifA in the diazotrophic endophyte Azoarcus sp. strain BH72.

4 of 23

1.79

1.67

0.00027

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:215

RNA polymerase, and Transcription termination

3 of 5

2.33

1.63

0.00087

CL:92

Ribosome, and RNA polymerase

4 of 67

1.32

0.8

0.0141

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

rsp03020

RNA polymerase

4 of 4

2.55

3.46

2.66e-07

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000428

DNA-directed RNA polymerase complex

7 of 66

1.57

2.47

6.05e-08

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0240

DNA-directed RNA polymerase

4 of 9

2.2

2.63

5.88e-06

KW-0731

Sigma factor

3 of 15

1.85

1.51

0.00081

KW-0804

Transcription

7 of 150

1.22

1.43

5.88e-06

KW-0548

Nucleotidyltransferase

4 of 45

1.5

1.36

0.00055

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04545

Sigma-70, region 4

3 of 7

2.18

1.52

0.0013

PF04542

Sigma-70 region 2

3 of 11

1.98

1.39

0.0019

PF00140

Sigma-70 factor, region 1.2

2 of 2

2.55

1.12

0.0091

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000943

RNA polymerase sigma-70

3 of 4

2.42

1.62

0.00096

IPR007630

RNA polymerase sigma-70 region 4

3 of 7

2.18

1.47

0.0016

IPR014284

RNA polymerase sigma-70 like domain

3 of 11

1.98

1.28

0.0033

IPR013325

RNA polymerase sigma factor, region 2

3 of 11

1.98

1.28

0.0033

IPR007627

RNA polymerase sigma-70 region 2

3 of 11

1.98

1.28

0.0033

(more ...)

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (14%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About