CMQ_748 protein (Grosmannia clavigera) - STRING interaction network

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second shell of interactors

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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CMQ_748

DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (153 aa)

Predicted Functional Partners:

CMQ_7003

0.999

CMQ_3277

0.999

CMQ_3985

0.999

CMQ_3942

0.999

CMQ_1687

0.999

CMQ_1652

0.999

CMQ_1596

0.999

CMQ_1555

0.999

CMQ_1170

0.999

CMQ_1366

0.999

Your Current Organism:

Grosmannia clavigera

NCBI taxonomy Id: 655863
Other names: G. clavigera kw1407, Grosmannia clavigera kw1407

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CMQ_1170	CMQ_1366	F0XE51	F0XEM1	DNA-directed RNA polymerase 1 and 3 subunit.	DNA-directed RNA polymerase 2 subunit.	0.982
CMQ_1170	CMQ_1555	F0XE51	F0XDY2	DNA-directed RNA polymerase 1 and 3 subunit.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.970
CMQ_1170	CMQ_1596	F0XE51	F0XDA2	DNA-directed RNA polymerase 1 and 3 subunit.	RNA polymerase 2 subunit 7.	0.934
CMQ_1170	CMQ_1652	F0XE51	F0XCE4	DNA-directed RNA polymerase 1 and 3 subunit.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.999
CMQ_1170	CMQ_1687	F0XE51	F0XC91	DNA-directed RNA polymerase 1 and 3 subunit.	DNA directed RNA polymerase 2 polypeptide d.	0.980
CMQ_1170	CMQ_3277	F0XE51	F0X9F9	DNA-directed RNA polymerase 1 and 3 subunit.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.999
CMQ_1170	CMQ_3942	F0XE51	F0XAJ3	DNA-directed RNA polymerase 1 and 3 subunit.	DNA-directed RNA polymerases n subunit superfamily.	0.999
CMQ_1170	CMQ_3985	F0XE51	F0XA62	DNA-directed RNA polymerase 1 and 3 subunit.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.999
CMQ_1170	CMQ_7003	F0XE51	F0X7X1	DNA-directed RNA polymerase 1 and 3 subunit.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.999
CMQ_1170	CMQ_748	F0XE51	F0XFD4	DNA-directed RNA polymerase 1 and 3 subunit.	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.	0.999
CMQ_1366	CMQ_1170	F0XEM1	F0XE51	DNA-directed RNA polymerase 2 subunit.	DNA-directed RNA polymerase 1 and 3 subunit.	0.982
CMQ_1366	CMQ_1555	F0XEM1	F0XDY2	DNA-directed RNA polymerase 2 subunit.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.999
CMQ_1366	CMQ_1596	F0XEM1	F0XDA2	DNA-directed RNA polymerase 2 subunit.	RNA polymerase 2 subunit 7.	0.999
CMQ_1366	CMQ_1652	F0XEM1	F0XCE4	DNA-directed RNA polymerase 2 subunit.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.461
CMQ_1366	CMQ_1687	F0XEM1	F0XC91	DNA-directed RNA polymerase 2 subunit.	DNA directed RNA polymerase 2 polypeptide d.	0.999
CMQ_1366	CMQ_3277	F0XEM1	F0X9F9	DNA-directed RNA polymerase 2 subunit.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.936
CMQ_1366	CMQ_3942	F0XEM1	F0XAJ3	DNA-directed RNA polymerase 2 subunit.	DNA-directed RNA polymerases n subunit superfamily.	0.999
CMQ_1366	CMQ_3985	F0XEM1	F0XA62	DNA-directed RNA polymerase 2 subunit.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.921
CMQ_1366	CMQ_7003	F0XEM1	F0X7X1	DNA-directed RNA polymerase 2 subunit.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.416
CMQ_1366	CMQ_748	F0XEM1	F0XFD4	DNA-directed RNA polymerase 2 subunit.	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.	0.999

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Network Stats

number of nodes:

11

number of edges:

24

average node degree:

4.36

avg. local clustering coefficient:

0.81

expected number of edges:

11

PPI enrichment p-value:

0.000469

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016126

Sterol biosynthetic process

3 of 19

2.38

1.71

0.00062

GO:0008610

Lipid biosynthetic process

6 of 304

1.48

1.56

9.58e-05

GO:0140647

P450-containing electron transport chain

2 of 2

3.18

1.43

0.0027

GO:0006629

Lipid metabolic process

7 of 717

1.17

1.12

0.00023

GO:0051353

Positive regulation of oxidoreductase activity

2 of 16

2.28

0.84

0.0286

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016717

Oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

3 of 5

2.96

2.69

1.24e-05

GO:0005506

Iron ion binding

5 of 147

1.71

2.03

1.81e-05

GO:0016491

Oxidoreductase activity

9 of 735

1.27

1.76

7.05e-08

GO:0016705

Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

5 of 201

1.58

1.72

6.20e-05

GO:0000254

C-4 methylsterol oxidase activity

2 of 3

3.0

1.55

0.0016

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005789

Endoplasmic reticulum membrane

5 of 518

1.17

0.82

0.0063

GO:0005783

Endoplasmic reticulum

6 of 815

1.05

0.76

0.0056

GO:0005737

Cytoplasm

11 of 6418

0.41

0.33

0.0063

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7252

Cytochrome P450 - arranged by substrate type, and Steroid biosynthetic process

8 of 138

1.94

4.42

5.66e-12

CL:7249

Mixed, incl. Cytochrome P450 - arranged by substrate type, and Short-chain dehydrogenase/reductase SDR

9 of 199

1.84

4.27

8.16e-13

CL:7431

Mixed, incl. Sterol biosynthetic process, and 3-beta-hydroxy-delta5-steroid dehydrogenase activity

5 of 39

2.29

3.74

2.85e-08

CL:7434

Mixed, incl. Fatty acid hydroxylase, and Steroid biosynthesis

4 of 22

2.44

3.22

6.26e-07

CL:7380

Electron transport from NADPH to Ferredoxin, and Fatty acid desaturase

3 of 5

2.96

2.94

4.21e-06

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8957322

Metabolism of steroids

6 of 93

1.99

3.4

2.26e-08

MAP-556833

Metabolism of lipids

8 of 574

1.32

1.83

2.10e-07

MAP-2395516

Electron transport from NADPH to Ferredoxin

2 of 3

3.0

1.6

0.0013

MAP-196108

Pregnenolone biosynthesis

2 of 7

2.64

1.33

0.0038

MAP-1362409

Mitochondrial iron-sulfur cluster biogenesis

2 of 10

2.48

1.22

0.0058

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04116

Fatty acid hydroxylase

4 of 9

2.83

3.81

8.88e-08

PF00487

Fatty acid desaturase

2 of 4

2.88

1.35

0.0036

PF00111

2Fe-2S iron-sulfur cluster binding domain

2 of 6

2.7

1.29

0.0045

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006694

Fatty acid hydroxylase

4 of 9

2.83

3.55

2.76e-07

IPR001055

Adrenodoxin

2 of 2

3.18

1.3

0.0045

IPR005804

Fatty acid desaturase domain

2 of 4

2.88

1.18

0.0075

IPR036400

Cytochrome b5-like heme/steroid binding domain superfamily

2 of 8

2.58

1.03

0.0135

IPR036010

2Fe-2S ferredoxin-like superfamily

2 of 7

2.64

1.03

0.0135

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01117

Cytochrome b5-like Heme/Steroid binding domain

2 of 8

2.58

1.12

0.0091

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