node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKM29034.1 | AKM29860.1 | AB870_01170 | AB870_06640 | Serine/threonine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Aminodeoxychorismate synthase component I; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.473 |
AKM29034.1 | glyA | AB870_01170 | AB870_04200 | Serine/threonine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.908 |
AKM29034.1 | ilvA | AB870_01170 | AB870_15295 | Serine/threonine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. | PLP-dependent threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.922 |
AKM29034.1 | trpA | AB870_01170 | AB870_20050 | Serine/threonine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.917 |
AKM29034.1 | trpB | AB870_01170 | AB870_20040 | Serine/threonine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.925 |
AKM29860.1 | AKM29034.1 | AB870_06640 | AB870_01170 | Aminodeoxychorismate synthase component I; Derived by automated computational analysis using gene prediction method: Protein Homology. | Serine/threonine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.473 |
AKM29860.1 | AKM30182.1 | AB870_06640 | AB870_08785 | Aminodeoxychorismate synthase component I; Derived by automated computational analysis using gene prediction method: Protein Homology. | Aminodeoxychorismate/anthranilate synthase component II; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.999 |
AKM29860.1 | glyA | AB870_06640 | AB870_04200 | Aminodeoxychorismate synthase component I; Derived by automated computational analysis using gene prediction method: Protein Homology. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.561 |
AKM29860.1 | ilvA | AB870_06640 | AB870_15295 | Aminodeoxychorismate synthase component I; Derived by automated computational analysis using gene prediction method: Protein Homology. | PLP-dependent threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.473 |
AKM29860.1 | trpA | AB870_06640 | AB870_20050 | Aminodeoxychorismate synthase component I; Derived by automated computational analysis using gene prediction method: Protein Homology. | Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.975 |
AKM29860.1 | trpB | AB870_06640 | AB870_20040 | Aminodeoxychorismate synthase component I; Derived by automated computational analysis using gene prediction method: Protein Homology. | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.972 |
AKM29860.1 | trpC | AB870_06640 | AB870_08795 | Aminodeoxychorismate synthase component I; Derived by automated computational analysis using gene prediction method: Protein Homology. | Indole-3-glycerol-phosphate synthase; Involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TrpC family. | 0.989 |
AKM29860.1 | trpD | AB870_06640 | AB870_08790 | Aminodeoxychorismate synthase component I; Derived by automated computational analysis using gene prediction method: Protein Homology. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.989 |
AKM29860.1 | trpE | AB870_06640 | AB870_08730 | Aminodeoxychorismate synthase component I; Derived by automated computational analysis using gene prediction method: Protein Homology. | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] | 0.878 |
AKM29860.1 | trpF | AB870_06640 | AB870_20035 | Aminodeoxychorismate synthase component I; Derived by automated computational analysis using gene prediction method: Protein Homology. | N-(5'-phosphoribosyl)anthranilate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TrpF family. | 0.942 |
AKM30182.1 | AKM29860.1 | AB870_08785 | AB870_06640 | Aminodeoxychorismate/anthranilate synthase component II; Derived by automated computational analysis using gene prediction method: Protein Homology. | Aminodeoxychorismate synthase component I; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.999 |
AKM30182.1 | trpA | AB870_08785 | AB870_20050 | Aminodeoxychorismate/anthranilate synthase component II; Derived by automated computational analysis using gene prediction method: Protein Homology. | Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.981 |
AKM30182.1 | trpB | AB870_08785 | AB870_20040 | Aminodeoxychorismate/anthranilate synthase component II; Derived by automated computational analysis using gene prediction method: Protein Homology. | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.981 |
AKM30182.1 | trpC | AB870_08785 | AB870_08795 | Aminodeoxychorismate/anthranilate synthase component II; Derived by automated computational analysis using gene prediction method: Protein Homology. | Indole-3-glycerol-phosphate synthase; Involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TrpC family. | 0.999 |
AKM30182.1 | trpD | AB870_08785 | AB870_08790 | Aminodeoxychorismate/anthranilate synthase component II; Derived by automated computational analysis using gene prediction method: Protein Homology. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.999 |