STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ALO65565.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (181 aa)    
Predicted Functional Partners:
gyrA
DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
  
  
 0.943
gyrB
DNA topoisomerase IV subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
       0.745
ALO66426.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.713
ALO66573.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.679
ALO68383.1
Hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.665
ALO68670.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.661
ALO67379.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.644
whiB
WhiB family transcriptional regulator; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA.
  
     0.626
ALO67565.1
Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
     0.622
ALO65348.1
Fructose-2,6-bisphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.605
Your Current Organism:
Arthrobacter alpinus
NCBI taxonomy Id: 656366
Other names: A. alpinus, Arthrobacter alpinus Zhang et al. 2010, Arthrobacter sp. A3, Arthrobacter sp. S6-3, CGMCC 1.8950, DSM 22274, strain S6-3
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