Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ADQ13668.1PFAM: malic protein NAD-binding; malic protein domain protein; KEGG: bbe:BBR47_13780 probable NAD-dependent malic enzyme. (408 aa)    
Predicted Functional Partners:
ADQ15234.1
KEGG: hor:Hore_03220 pyruvate kinase; TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; PEP-utilising protein mobile region; Belongs to the pyruvate kinase family.
  
 0.953
ADQ13669.1
PFAM: malic protein NAD-binding; malic protein domain protein; KEGG: bsu:BSU29220 NADP-dependent malic enzyme (conversion of malate into pyruvate).
 
  
 
0.948
ldh
L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family.
  
 0.943
ADQ15738.1
KEGG: hor:Hore_20820 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; Pyruvate-flavodoxin oxidoreductase, EKR domain; thiamine pyrophosphate TPP-binding domain-containing protein.
  
 
 0.940
fumC
Fumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
  
 
 0.935
ADQ14637.1
Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
   
 0.930
ADQ13672.1
TIGRFAM: pyruvate, phosphate dikinase; KEGG: tte:TTE0981 pyruvate phosphate dikinase; PFAM: pyruvate phosphate dikinase PEP/pyruvate-binding; PEP-utilising protein mobile region; PEP-utilizing protein.
  
 
 0.926
ADQ14245.1
PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; KEGG: hor:Hore_05280 pyruvate ferredoxin oxidoreductase, alpha subunit.
   
 
 0.924
ADQ14981.1
KEGG: hor:Hore_10200 phosphate acetyltransferase; TIGRFAM: phosphate acetyltransferase; PFAM: phosphate acetyl/butaryl transferase.
 
 
  
 0.915
ADQ15268.1
TIGRFAM: pyruvate, phosphate dikinase; KEGG: tte:TTE0981 pyruvate phosphate dikinase; PFAM: pyruvate phosphate dikinase PEP/pyruvate-binding; PEP-utilising protein mobile region; PEP-utilizing protein.
   
 
 0.909
Your Current Organism:
Halanaerobium hydrogeniformans
NCBI taxonomy Id: 656519
Other names: H. hydrogeniformans, Halanaerobium sapolanicus, strain SL-HP
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