node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADQ14318.1 | ADQ14319.1 | Halsa_0871 | Halsa_0872 | N-acetylmuramoyl-L-alanine amidase; PFAM: cell wall hydrolase/autolysin; KEGG: hor:Hore_15510 N-acetylmuramoyl-L-alanine amidase; SMART: cell wall hydrolase/autolysin. | PFAM: Lipoprotein LpqB, GerMN domain; KEGG: hor:Hore_15500 hypothetical protein. | 0.811 |
ADQ14318.1 | ADQ14322.1 | Halsa_0871 | Halsa_0875 | N-acetylmuramoyl-L-alanine amidase; PFAM: cell wall hydrolase/autolysin; KEGG: hor:Hore_15510 N-acetylmuramoyl-L-alanine amidase; SMART: cell wall hydrolase/autolysin. | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.776 |
ADQ14318.1 | murI | Halsa_0871 | Halsa_0873 | N-acetylmuramoyl-L-alanine amidase; PFAM: cell wall hydrolase/autolysin; KEGG: hor:Hore_15510 N-acetylmuramoyl-L-alanine amidase; SMART: cell wall hydrolase/autolysin. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.774 |
ADQ14318.1 | rph | Halsa_0871 | Halsa_0874 | N-acetylmuramoyl-L-alanine amidase; PFAM: cell wall hydrolase/autolysin; KEGG: hor:Hore_15510 N-acetylmuramoyl-L-alanine amidase; SMART: cell wall hydrolase/autolysin. | Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.745 |
ADQ14319.1 | ADQ14318.1 | Halsa_0872 | Halsa_0871 | PFAM: Lipoprotein LpqB, GerMN domain; KEGG: hor:Hore_15500 hypothetical protein. | N-acetylmuramoyl-L-alanine amidase; PFAM: cell wall hydrolase/autolysin; KEGG: hor:Hore_15510 N-acetylmuramoyl-L-alanine amidase; SMART: cell wall hydrolase/autolysin. | 0.811 |
ADQ14319.1 | ADQ14322.1 | Halsa_0872 | Halsa_0875 | PFAM: Lipoprotein LpqB, GerMN domain; KEGG: hor:Hore_15500 hypothetical protein. | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.745 |
ADQ14319.1 | murI | Halsa_0872 | Halsa_0873 | PFAM: Lipoprotein LpqB, GerMN domain; KEGG: hor:Hore_15500 hypothetical protein. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.735 |
ADQ14319.1 | rph | Halsa_0872 | Halsa_0874 | PFAM: Lipoprotein LpqB, GerMN domain; KEGG: hor:Hore_15500 hypothetical protein. | Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.750 |
ADQ14322.1 | ADQ14318.1 | Halsa_0875 | Halsa_0871 | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | N-acetylmuramoyl-L-alanine amidase; PFAM: cell wall hydrolase/autolysin; KEGG: hor:Hore_15510 N-acetylmuramoyl-L-alanine amidase; SMART: cell wall hydrolase/autolysin. | 0.776 |
ADQ14322.1 | ADQ14319.1 | Halsa_0875 | Halsa_0872 | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | PFAM: Lipoprotein LpqB, GerMN domain; KEGG: hor:Hore_15500 hypothetical protein. | 0.745 |
ADQ14322.1 | murI | Halsa_0875 | Halsa_0873 | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.981 |
ADQ14322.1 | rph | Halsa_0875 | Halsa_0874 | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.991 |
ADQ14811.1 | rnr | Halsa_1384 | Halsa_0858 | PFAM: NUDIX hydrolase; KEGG: tpd:Teth39_1115 NUDIX hydrolase. | Ribonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. | 0.828 |
ADQ14811.1 | rph | Halsa_1384 | Halsa_0874 | PFAM: NUDIX hydrolase; KEGG: tpd:Teth39_1115 NUDIX hydrolase. | Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.746 |
ADQ15345.1 | ispH | Halsa_1927 | Halsa_1544 | PFAM: ribosomal protein L7Ae/L30e/S12e/Gadd45; KEGG: hor:Hore_01110 ribosomal protein L7Ae/L30e/S12e/Gadd45. | Hydroxymethylbutenyl pyrophosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. | 0.734 |
ADQ15345.1 | rnr | Halsa_1927 | Halsa_0858 | PFAM: ribosomal protein L7Ae/L30e/S12e/Gadd45; KEGG: hor:Hore_01110 ribosomal protein L7Ae/L30e/S12e/Gadd45. | Ribonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. | 0.447 |
ADQ15345.1 | rph | Halsa_1927 | Halsa_0874 | PFAM: ribosomal protein L7Ae/L30e/S12e/Gadd45; KEGG: hor:Hore_01110 ribosomal protein L7Ae/L30e/S12e/Gadd45. | Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.797 |
ADQ15345.1 | rpsD | Halsa_1927 | Halsa_1895 | PFAM: ribosomal protein L7Ae/L30e/S12e/Gadd45; KEGG: hor:Hore_01110 ribosomal protein L7Ae/L30e/S12e/Gadd45. | Ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. | 0.994 |
ADQ15345.1 | rpsK | Halsa_1927 | Halsa_1896 | PFAM: ribosomal protein L7Ae/L30e/S12e/Gadd45; KEGG: hor:Hore_01110 ribosomal protein L7Ae/L30e/S12e/Gadd45. | 30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. | 0.994 |
ispH | ADQ15345.1 | Halsa_1544 | Halsa_1927 | Hydroxymethylbutenyl pyrophosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. | PFAM: ribosomal protein L7Ae/L30e/S12e/Gadd45; KEGG: hor:Hore_01110 ribosomal protein L7Ae/L30e/S12e/Gadd45. | 0.734 |