| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADQ13667.1 | ADQ14235.1 | Halsa_0178 | Halsa_0788 | KEGG: chy:CHY_0713 alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase; TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region. | KEGG: hor:Hore_21030 dihydrolipoamide dehydrogenase; TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region. | 0.905 |
| ADQ13667.1 | ADQ14386.1 | Halsa_0178 | Halsa_0940 | KEGG: chy:CHY_0713 alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase; TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region. | KEGG: gbe:GbCGDNIH1_0050 methylenetetrahydrofolate dehydrogenase (NADP+); PFAM: Methylene-tetrahydromethanopterin dehydrogenase. | 0.903 |
| ADQ13667.1 | ADQ15134.1 | Halsa_0178 | Halsa_1711 | KEGG: chy:CHY_0713 alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase; TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region. | TIGRFAM: 5,10-methylenetetrahydrofolate reductase; KEGG: cbi:CLJ_B1732 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.914 |
| ADQ13667.1 | gcvH | Halsa_0178 | Halsa_2379 | KEGG: chy:CHY_0713 alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase; TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.978 |
| ADQ13667.1 | glyA | Halsa_0178 | Halsa_0831 | KEGG: chy:CHY_0713 alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase; TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.916 |
| ADQ14235.1 | ADQ13667.1 | Halsa_0788 | Halsa_0178 | KEGG: hor:Hore_21030 dihydrolipoamide dehydrogenase; TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region. | KEGG: chy:CHY_0713 alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase; TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region. | 0.905 |
| ADQ14235.1 | ADQ14386.1 | Halsa_0788 | Halsa_0940 | KEGG: hor:Hore_21030 dihydrolipoamide dehydrogenase; TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region. | KEGG: gbe:GbCGDNIH1_0050 methylenetetrahydrofolate dehydrogenase (NADP+); PFAM: Methylene-tetrahydromethanopterin dehydrogenase. | 0.903 |
| ADQ14235.1 | ADQ15134.1 | Halsa_0788 | Halsa_1711 | KEGG: hor:Hore_21030 dihydrolipoamide dehydrogenase; TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region. | TIGRFAM: 5,10-methylenetetrahydrofolate reductase; KEGG: cbi:CLJ_B1732 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.914 |
| ADQ14235.1 | gcvH | Halsa_0788 | Halsa_2379 | KEGG: hor:Hore_21030 dihydrolipoamide dehydrogenase; TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.977 |
| ADQ14235.1 | glyA | Halsa_0788 | Halsa_0831 | KEGG: hor:Hore_21030 dihydrolipoamide dehydrogenase; TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.916 |
| ADQ14386.1 | ADQ13667.1 | Halsa_0940 | Halsa_0178 | KEGG: gbe:GbCGDNIH1_0050 methylenetetrahydrofolate dehydrogenase (NADP+); PFAM: Methylene-tetrahydromethanopterin dehydrogenase. | KEGG: chy:CHY_0713 alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase; TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region. | 0.903 |
| ADQ14386.1 | ADQ14235.1 | Halsa_0940 | Halsa_0788 | KEGG: gbe:GbCGDNIH1_0050 methylenetetrahydrofolate dehydrogenase (NADP+); PFAM: Methylene-tetrahydromethanopterin dehydrogenase. | KEGG: hor:Hore_21030 dihydrolipoamide dehydrogenase; TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region. | 0.903 |
| ADQ14386.1 | ADQ14387.1 | Halsa_0940 | Halsa_0941 | KEGG: gbe:GbCGDNIH1_0050 methylenetetrahydrofolate dehydrogenase (NADP+); PFAM: Methylene-tetrahydromethanopterin dehydrogenase. | PFAM: protein of unknown function DUF201; KEGG: meh:M301_1555 protein of unknown function DUF201. | 0.950 |
| ADQ14386.1 | ADQ14390.1 | Halsa_0940 | Halsa_0944 | KEGG: gbe:GbCGDNIH1_0050 methylenetetrahydrofolate dehydrogenase (NADP+); PFAM: Methylene-tetrahydromethanopterin dehydrogenase. | KEGG: mfs:MFS40622_0802 formylmethanofuran dehydrogenase subunit A; TIGRFAM: formylmethanofuran dehydrogenase subunit A; PFAM: Amidohydrolase 3. | 0.908 |
| ADQ14386.1 | ADQ14392.1 | Halsa_0940 | Halsa_0946 | KEGG: gbe:GbCGDNIH1_0050 methylenetetrahydrofolate dehydrogenase (NADP+); PFAM: Methylene-tetrahydromethanopterin dehydrogenase. | TIGRFAM: formylmethanofuran dehydrogenase subunit C; KEGG: mth:MTH918 molybdenum formylmethanofuran dehydrogenase, subunit C; PFAM: glutamate synthase alpha subunit domain protein. | 0.907 |
| ADQ14386.1 | ADQ15134.1 | Halsa_0940 | Halsa_1711 | KEGG: gbe:GbCGDNIH1_0050 methylenetetrahydrofolate dehydrogenase (NADP+); PFAM: Methylene-tetrahydromethanopterin dehydrogenase. | TIGRFAM: 5,10-methylenetetrahydrofolate reductase; KEGG: cbi:CLJ_B1732 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.903 |
| ADQ14386.1 | ffsA | Halsa_0940 | Halsa_0945 | KEGG: gbe:GbCGDNIH1_0050 methylenetetrahydrofolate dehydrogenase (NADP+); PFAM: Methylene-tetrahydromethanopterin dehydrogenase. | Formylmethanofuran/tetrahydromethanopterin N-formyltransferase; Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT); Belongs to the FTR family. | 0.908 |
| ADQ14386.1 | gcvH | Halsa_0940 | Halsa_2379 | KEGG: gbe:GbCGDNIH1_0050 methylenetetrahydrofolate dehydrogenase (NADP+); PFAM: Methylene-tetrahydromethanopterin dehydrogenase. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.901 |
| ADQ14386.1 | glyA | Halsa_0940 | Halsa_0831 | KEGG: gbe:GbCGDNIH1_0050 methylenetetrahydrofolate dehydrogenase (NADP+); PFAM: Methylene-tetrahydromethanopterin dehydrogenase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.902 |
| ADQ14386.1 | mch | Halsa_0940 | Halsa_0947 | KEGG: gbe:GbCGDNIH1_0050 methylenetetrahydrofolate dehydrogenase (NADP+); PFAM: Methylene-tetrahydromethanopterin dehydrogenase. | Methenyltetrahydromethanopterin cyclohydrolase; Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl- H(4)MPT; Belongs to the MCH family. | 0.991 |