ADQ14417.1 protein (Halanaerobium hydrogeniformans)

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second shell of interactors

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Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

ADQ14417.1

KEGG: cac:CA_C0748 nitroreductase family protein. (262 aa)

Predicted Functional Partners:

ADQ14416.1

0.635

ADQ14418.1

0.581

ADQ14628.1

0.529

ADQ14415.1

0.419

ribBA

0.415

Your Current Organism:

Halanaerobium hydrogeniformans

NCBI taxonomy Id: 656519
Other names: H. hydrogeniformans, Halanaerobium sapolanicus, strain SL-HP

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADQ14415.1	ADQ14416.1	Halsa_0970	Halsa_0971	PFAM: macrophage migration inhibitory factor family protein; KEGG: pmo:Pmob_1555 macrophage migration inhibitory factor family protein.	PFAM: phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; phosphoglucomutase/phosphomannomutase; KEGG: sti:Sthe_1355 phosphomannomutase.	0.511
ADQ14415.1	ADQ14417.1	Halsa_0970	Halsa_0972	PFAM: macrophage migration inhibitory factor family protein; KEGG: pmo:Pmob_1555 macrophage migration inhibitory factor family protein.	KEGG: cac:CA_C0748 nitroreductase family protein.	0.419
ADQ14416.1	ADQ14415.1	Halsa_0971	Halsa_0970	PFAM: phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; phosphoglucomutase/phosphomannomutase; KEGG: sti:Sthe_1355 phosphomannomutase.	PFAM: macrophage migration inhibitory factor family protein; KEGG: pmo:Pmob_1555 macrophage migration inhibitory factor family protein.	0.511
ADQ14416.1	ADQ14417.1	Halsa_0971	Halsa_0972	PFAM: phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; phosphoglucomutase/phosphomannomutase; KEGG: sti:Sthe_1355 phosphomannomutase.	KEGG: cac:CA_C0748 nitroreductase family protein.	0.635
ADQ14417.1	ADQ14415.1	Halsa_0972	Halsa_0970	KEGG: cac:CA_C0748 nitroreductase family protein.	PFAM: macrophage migration inhibitory factor family protein; KEGG: pmo:Pmob_1555 macrophage migration inhibitory factor family protein.	0.419
ADQ14417.1	ADQ14416.1	Halsa_0972	Halsa_0971	KEGG: cac:CA_C0748 nitroreductase family protein.	PFAM: phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; phosphoglucomutase/phosphomannomutase; KEGG: sti:Sthe_1355 phosphomannomutase.	0.635
ADQ14417.1	ADQ14418.1	Halsa_0972	Halsa_0973	KEGG: cac:CA_C0748 nitroreductase family protein.	PFAM: aldo/keto reductase; KEGG: hor:Hore_07500 aldo/keto reductase.	0.581
ADQ14417.1	ADQ14628.1	Halsa_0972	Halsa_1197	KEGG: cac:CA_C0748 nitroreductase family protein.	KEGG: cdl:CDR20291_1317 putative iron-sulfur protein.	0.529
ADQ14417.1	ribBA	Halsa_0972	Halsa_1152	KEGG: cac:CA_C0748 nitroreductase family protein.	3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.	0.415
ADQ14418.1	ADQ14417.1	Halsa_0973	Halsa_0972	PFAM: aldo/keto reductase; KEGG: hor:Hore_07500 aldo/keto reductase.	KEGG: cac:CA_C0748 nitroreductase family protein.	0.581
ADQ14628.1	ADQ14417.1	Halsa_1197	Halsa_0972	KEGG: cdl:CDR20291_1317 putative iron-sulfur protein.	KEGG: cac:CA_C0748 nitroreductase family protein.	0.529
ribBA	ADQ14417.1	Halsa_1152	Halsa_0972	3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.	KEGG: cac:CA_C0748 nitroreductase family protein.	0.415

Network Stats

number of nodes:

9

number of edges:

23

average node degree:

5.11

avg. local clustering coefficient:

0.889

expected number of edges:

8

PPI enrichment p-value:

1.25e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006449

Regulation of translational termination

2 of 3

3.14

1.38

0.0033

GO:0016973

poly(A)+ mRNA export from nucleus

2 of 6

2.84

1.37

0.0033

GO:0006446

Regulation of translational initiation

2 of 6

2.84

1.37

0.0033

GO:0050658

RNA transport

3 of 44

2.15

1.31

0.0033

GO:0006913

Nucleocytoplasmic transport

3 of 109

1.76

1.21

0.0033

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005198

Structural molecule activity

6 of 195

1.81

2.77

2.33e-07

GO:0003735

Structural constituent of ribosome

4 of 125

1.83

1.76

0.00019

GO:0000822

Inositol hexakisphosphate binding

2 of 3

3.14

1.69

0.00088

GO:0031369

Translation initiation factor binding

2 of 10

2.62

1.29

0.0044

GO:0005543

Phospholipid binding

2 of 41

2.01

0.75

0.0395

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005643

Nuclear pore

3 of 21

2.48

2.14

0.00010

GO:0044614

Nuclear pore cytoplasmic filaments

2 of 2

3.32

2.05

0.00020

GO:0005840

Ribosome

4 of 136

1.79

1.8

0.00013

GO:0044391

Ribosomal subunit

3 of 91

1.84

1.42

0.0013

GO:0022627

Cytosolic small ribosomal subunit

2 of 19

2.34

1.3

0.0039

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7298

Formation of the ternary complex, and subsequently, the 43S complex

4 of 24

2.54

3.15

1.10e-06

CL:6165

Mixed, incl. LCCL domain, and CalX-like domain superfamily

2 of 12

2.54

1.46

0.0021

CL:8956

Nuclear pore

2 of 13

2.51

1.43

0.0023

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03010

Ribosome

4 of 157

1.73

1.79

9.92e-05

map03013

RNA transport

3 of 196

1.51

0.99

0.0068

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72695

Formation of the ternary complex, and subsequently, the 43S complex

4 of 53

2.2

2.58

7.71e-06

MAP-72702

Ribosomal scanning and start codon recognition

4 of 56

2.17

2.57

7.71e-06

MAP-72706

GTP hydrolysis and joining of the 60S ribosomal subunit

4 of 79

2.03

2.4

1.07e-05

MAP-72689

Formation of a pool of free 40S subunits

4 of 90

1.97

2.31

1.42e-05

MAP-1799339

SRP-dependent cotranslational protein targeting to membrane

4 of 91

1.96

2.31

1.42e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005643

Nuclear pore

3 of 24

2.42

2.0

0.00018

GOCC:0022627

Cytosolic small ribosomal subunit

2 of 13

2.51

1.39

0.0028

GOCC:0032991

Protein-containing complex

7 of 1843

0.9

0.74

0.0013

GOCC:0005634

Nucleus

4 of 892

0.97

0.55

0.0309

GOCC:0043226

Organelle

9 of 4415

0.63

0.48

0.0025

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

3 of 57

2.04

1.64

0.00060

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