node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADQ15361.1 | ADQ15364.1 | Halsa_1943 | Halsa_1946 | Putative signal transduction protein with CBS domains; KEGG: hor:Hore_00940 CBS domain containing protein; PFAM: CBS domain containing protein; HutP family protein; SMART: CBS domain containing protein. | KEGG: hor:Hore_00910 PilT protein domain protein; PFAM: PilT protein domain protein; deoxyribonuclease/rho motif-related TRAM; SMART: Nucleotide binding protein PINc. | 0.740 |
ADQ15361.1 | ADQ15365.1 | Halsa_1943 | Halsa_1947 | Putative signal transduction protein with CBS domains; KEGG: hor:Hore_00940 CBS domain containing protein; PFAM: CBS domain containing protein; HutP family protein; SMART: CBS domain containing protein. | PFAM: transcription factor CarD; KEGG: hor:Hore_00900 transcriptional regulator, CarD family. | 0.637 |
ADQ15361.1 | disA | Halsa_1943 | Halsa_1948 | Putative signal transduction protein with CBS domains; KEGG: hor:Hore_00940 CBS domain containing protein; PFAM: CBS domain containing protein; HutP family protein; SMART: CBS domain containing protein. | DNA integrity scanning, DisA, linker region; Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis. | 0.427 |
ADQ15361.1 | gltX | Halsa_1943 | Halsa_1942 | Putative signal transduction protein with CBS domains; KEGG: hor:Hore_00940 CBS domain containing protein; PFAM: CBS domain containing protein; HutP family protein; SMART: CBS domain containing protein. | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. | 0.703 |
ADQ15361.1 | ispD | Halsa_1943 | Halsa_1945 | Putative signal transduction protein with CBS domains; KEGG: hor:Hore_00940 CBS domain containing protein; PFAM: CBS domain containing protein; HutP family protein; SMART: CBS domain containing protein. | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). | 0.775 |
ADQ15361.1 | ispF | Halsa_1943 | Halsa_1944 | Putative signal transduction protein with CBS domains; KEGG: hor:Hore_00940 CBS domain containing protein; PFAM: CBS domain containing protein; HutP family protein; SMART: CBS domain containing protein. | 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). | 0.773 |
ADQ15364.1 | ADQ15361.1 | Halsa_1946 | Halsa_1943 | KEGG: hor:Hore_00910 PilT protein domain protein; PFAM: PilT protein domain protein; deoxyribonuclease/rho motif-related TRAM; SMART: Nucleotide binding protein PINc. | Putative signal transduction protein with CBS domains; KEGG: hor:Hore_00940 CBS domain containing protein; PFAM: CBS domain containing protein; HutP family protein; SMART: CBS domain containing protein. | 0.740 |
ADQ15364.1 | ADQ15365.1 | Halsa_1946 | Halsa_1947 | KEGG: hor:Hore_00910 PilT protein domain protein; PFAM: PilT protein domain protein; deoxyribonuclease/rho motif-related TRAM; SMART: Nucleotide binding protein PINc. | PFAM: transcription factor CarD; KEGG: hor:Hore_00900 transcriptional regulator, CarD family. | 0.734 |
ADQ15364.1 | disA | Halsa_1946 | Halsa_1948 | KEGG: hor:Hore_00910 PilT protein domain protein; PFAM: PilT protein domain protein; deoxyribonuclease/rho motif-related TRAM; SMART: Nucleotide binding protein PINc. | DNA integrity scanning, DisA, linker region; Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis. | 0.672 |
ADQ15364.1 | gltX | Halsa_1946 | Halsa_1942 | KEGG: hor:Hore_00910 PilT protein domain protein; PFAM: PilT protein domain protein; deoxyribonuclease/rho motif-related TRAM; SMART: Nucleotide binding protein PINc. | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. | 0.729 |
ADQ15364.1 | ispD | Halsa_1946 | Halsa_1945 | KEGG: hor:Hore_00910 PilT protein domain protein; PFAM: PilT protein domain protein; deoxyribonuclease/rho motif-related TRAM; SMART: Nucleotide binding protein PINc. | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). | 0.847 |
ADQ15364.1 | ispF | Halsa_1946 | Halsa_1944 | KEGG: hor:Hore_00910 PilT protein domain protein; PFAM: PilT protein domain protein; deoxyribonuclease/rho motif-related TRAM; SMART: Nucleotide binding protein PINc. | 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). | 0.804 |
ADQ15365.1 | ADQ15361.1 | Halsa_1947 | Halsa_1943 | PFAM: transcription factor CarD; KEGG: hor:Hore_00900 transcriptional regulator, CarD family. | Putative signal transduction protein with CBS domains; KEGG: hor:Hore_00940 CBS domain containing protein; PFAM: CBS domain containing protein; HutP family protein; SMART: CBS domain containing protein. | 0.637 |
ADQ15365.1 | ADQ15364.1 | Halsa_1947 | Halsa_1946 | PFAM: transcription factor CarD; KEGG: hor:Hore_00900 transcriptional regulator, CarD family. | KEGG: hor:Hore_00910 PilT protein domain protein; PFAM: PilT protein domain protein; deoxyribonuclease/rho motif-related TRAM; SMART: Nucleotide binding protein PINc. | 0.734 |
ADQ15365.1 | disA | Halsa_1947 | Halsa_1948 | PFAM: transcription factor CarD; KEGG: hor:Hore_00900 transcriptional regulator, CarD family. | DNA integrity scanning, DisA, linker region; Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis. | 0.680 |
ADQ15365.1 | gltX | Halsa_1947 | Halsa_1942 | PFAM: transcription factor CarD; KEGG: hor:Hore_00900 transcriptional regulator, CarD family. | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. | 0.657 |
ADQ15365.1 | ispD | Halsa_1947 | Halsa_1945 | PFAM: transcription factor CarD; KEGG: hor:Hore_00900 transcriptional regulator, CarD family. | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). | 0.772 |
ADQ15365.1 | ispF | Halsa_1947 | Halsa_1944 | PFAM: transcription factor CarD; KEGG: hor:Hore_00900 transcriptional regulator, CarD family. | 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). | 0.712 |
ADQ15365.1 | ispH | Halsa_1947 | Halsa_1544 | PFAM: transcription factor CarD; KEGG: hor:Hore_00900 transcriptional regulator, CarD family. | Hydroxymethylbutenyl pyrophosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. | 0.453 |
disA | ADQ15361.1 | Halsa_1948 | Halsa_1943 | DNA integrity scanning, DisA, linker region; Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis. | Putative signal transduction protein with CBS domains; KEGG: hor:Hore_00940 CBS domain containing protein; PFAM: CBS domain containing protein; HutP family protein; SMART: CBS domain containing protein. | 0.427 |