Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ADQ15462.1PFAM: Aconitase B; aconitate hydratase domain-containing protein; KEGG: saf:SULAZ_1512 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase. (855 aa)    
Predicted Functional Partners:
ADQ15463.1
KEGG: cac:CA_C0972 isocitrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase.
 
  
 0.971
ADQ14630.1
PFAM: Citrate synthase; KEGG: cno:NT01CX_0234 citrate synthase.
  
 
 0.957
ldh
L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family.
  
  
 0.882
sucC
succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
  
 0.823
ADQ15464.1
KEGG: hor:Hore_22340 PHP domain protein; PFAM: PHP domain protein; SMART: phosphoesterase PHP domain protein.
       0.480
ADQ15465.1
PFAM: protein of unknown function DUF218; KEGG: hor:Hore_22350 hypothetical protein.
 
     0.479
ADQ15738.1
KEGG: hor:Hore_20820 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; Pyruvate-flavodoxin oxidoreductase, EKR domain; thiamine pyrophosphate TPP-binding domain-containing protein.
   
  
 0.458
ADQ13981.1
KEGG: hmo:HM1_1037 glutamate synthase [nadph] large chain; PFAM: ferredoxin-dependent glutamate synthase; glutamine amidotransferase class-II; glutamate synthase; glutamate synthase alpha subunit domain protein.
      
 0.424
sucD
succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
  
 0.414
ADQ15461.1
KEGG: mvn:Mevan_1192 hypothetical protein.
       0.402
Your Current Organism:
Halanaerobium hydrogeniformans
NCBI taxonomy Id: 656519
Other names: H. hydrogeniformans, Halanaerobium sapolanicus, strain SL-HP
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