Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
trpB-2Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (407 aa)    
Predicted Functional Partners:
trpA
Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
 0.999
trpC
KEGG: pmo:Pmob_1210 indole-3-glycerol-phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase; Belongs to the TrpC family.
 
 0.999
trpF
KEGG: pmo:Pmob_1209 phosphoribosylanthranilate isomerase; PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); Belongs to the TrpF family.
  
 0.997
ADQ14114.1
Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
 
 0.996
trpD
Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).
  
 0.965
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
     
 0.912
trpB
Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
  
  
 
0.902
ADQ13909.1
KEGG: mmp:MMP0739 Asp/Glu racemase:aspartate racemase; TIGRFAM: aspartate racemase; PFAM: Asp/Glu/hydantoin racemase; Belongs to the aspartate/glutamate racemases family.
     
  0.900
ADQ13951.1
TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, beta subunit; KEGG: hor:Hore_16340 L-serine ammonia-lyase, beta subunit; PFAM: serine dehydratase beta chain; amino acid-binding ACT domain protein.
     
  0.900
ADQ13952.1
TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, alpha subunit; KEGG: hor:Hore_16330 L-serine ammonia-lyase, alpha subunit; PFAM: serine dehydratase alpha chain.
     
  0.900
Your Current Organism:
Halanaerobium hydrogeniformans
NCBI taxonomy Id: 656519
Other names: H. hydrogeniformans, Halanaerobium sapolanicus, strain SL-HP
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