Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Experiments
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[Homology]
Score
ADQ15580.1KEGG: hor:Hore_19110 GAF domain-containing protein. (161 aa)    
Predicted Functional Partners:
ADQ14406.1
TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; KEGG: tpd:Teth39_0501 O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein.
    
  0.901
metK
S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
     
  0.900
ADQ15132.1
PFAM: homocysteine S-methyltransferase; dihydropteroate synthase DHPS; Methionine synthase B12-binding module cap domain protein; cobalamin B12-binding domain protein; KEGG: ctc:CTC01806 5-methyltetrahydrofolate--homocysteine methyltransferase.
     
  0.900
ADQ15579.1
HAD-superfamily hydrolase, subfamily IA, variant 1; KEGG: tmt:Tmath_0918 haloacid dehalogenase domain protein hydrolase; TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: Haloacid dehalogenase domain protein hydrolase.
       0.741
ADQ15131.1
PFAM: transferase hexapeptide repeat containing protein; KEGG: pmo:Pmob_0648 ferripyochelin binding protein (fbp).
      0.723
ADQ15581.1
PFAM: protein of unknown function DUF340 membrane; KEGG: hor:Hore_07210 predicted membrane protein.
       0.608
ADQ15582.1
PFAM: alanine racemase domain protein; KEGG: hor:Hore_19150 alanine racemase domain protein.
       0.543
msrA
methionine-R-sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
     
 0.468
nadK
ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
 
 
    0.464
Your Current Organism:
Halanaerobium hydrogeniformans
NCBI taxonomy Id: 656519
Other names: H. hydrogeniformans, Halanaerobium sapolanicus, strain SL-HP
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