STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADQ15708.1PFAM: metallophosphoesterase; 5'-Nucleotidase domain-containing protein; KEGG: nph:NP1854A 5'-nucleotidase 1; 2',3'-cyclic-nucleotide 2'-phosphodiesterase 1; UDP-sugar hydrolase 1; Belongs to the 5'-nucleotidase family. (661 aa)    
Predicted Functional Partners:
ADQ14378.1
PFAM: metallophosphoesterase; KEGG: amt:Amet_3610 5'-nucleotidase domain-containing protein.
  
  
 
0.927
ADQ15116.1
TIGRFAM: uridine kinase; KEGG: hor:Hore_12970 uridine kinase.
  
 
  0.920
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
    
 0.914
cinA
Competence/damage-inducible protein CinA; KEGG: bwe:BcerKBAB4_3551 competence damage-inducible protein A; TIGRFAM: competence/damage-inducible protein CinA; PFAM: molybdopterin binding domain; CinA domain protein; Belongs to the CinA family.
   
 
  0.913
ADQ14953.1
SMART: AAA ATPase; KEGG: hor:Hore_10770 uridine kinase.
  
 
  0.911
tmk
Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
   
 
  0.909
apt
Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
    
 0.909
ADQ14808.1
Inosine guanosine and xanthosine phosphorylase family; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
  
 
 0.908
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
    
 0.908
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
    
 0.907
Your Current Organism:
Halanaerobium hydrogeniformans
NCBI taxonomy Id: 656519
Other names: H. hydrogeniformans, Halanaerobium sapolanicus, strain SL-HP
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.