STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
metKMethionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (395 aa)    
Predicted Functional Partners:
SMB93363.1
Phosphopantothenate-cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family.
 
 
 0.959
SMB86768.1
InterPro IPR003171; COGs: COG0685 5 10-methylenetetrahydrofolate reductase; KEGG: gme:Gmet_1160 methylenetetrahydrofolate reductase; SPTR: Q8TKA0 5,10-methylenetetrahydrofolate reductase (FADH); PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.
  
 
 0.923
SMB88673.1
UDP-2-acetamido-2,6-beta-L-arabino-hexul-4-ose reductase; InterPro IPR000888:IPR013120:IPR001509; COGs: COG0451 Nucleoside-diphosphate-sugar epimerase; KEGG: gbm:Gbem_1622 NAD-dependent epimerase/dehydratase; PFAM: NAD-dependent epimerase/dehydratase; Male sterility domain; SPTR: A3WUD2 Probable NAD dependent epimerase/dehydratase, possibly involved in polysaccharide biosynthesis.
   
 0.920
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
 
   
 0.909
SMB86776.1
5-methyltetrahydrofolate--homocysteine methyltransferase; COGs: COG1410 Methionine synthase I cobalamin-binding domain; KEGG: geo:Geob_1365 homocysteine S-methyltransferase; SPTR: A5KL27 Putative uncharacterized protein; InterPro IPR006158:IPR003759:IPR003726:IPR000489; PFAM: homocysteine S-methyltransferase; cobalamin B12-binding domain protein; Methionine synthase B12-binding module cap domain protein; dihydropteroate synthase DHPS.
  
 
 0.906
ispF
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
    
 0.897
SMB88760.1
GDP-mannose 4,6 dehydratase; KEGG: neu:NE2277 NAD-dependent epimerase/dehydratase family protein; SPTR: A2SRW2 NAD-dependent epimerase/dehydratase.
   
 0.876
speD
S-adenosylmethionine decarboxylase; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily.
    
 0.862
ribH
6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
  
 
 0.850
rpoZ
DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
       0.837
Your Current Organism:
Desulfonispora thiosulfatigenes
NCBI taxonomy Id: 656914
Other names: D. thiosulfatigenes DSM 11270, Desulfonispora thiosulfatigenes DSM 11270, Desulfonispora thiosulfatigenes str. DSM 11270, Desulfonispora thiosulfatigenes strain DSM 11270
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