STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
proSprolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...] (567 aa)    
Predicted Functional Partners:
ileS
Isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
   
 0.991
argS
arginyl-tRNA synthetase; InterPro IPR015945:IPR005148:IPR008909:IPR001412:IPR001278; COGs: COG0018 Arginyl-tRNA synthetase; KEGG: sat:SYN_00994 arginyl-tRNA synthetase; SPTR: A4J9D2 Arginyl-tRNA synthetase; PFAM: Arginyl-tRNA synthetase, class Ic, core; arginyl tRNA synthetase domain protein; DALR anticodon binding domain protein; PRIAM: Arginine--tRNA ligase; TIGRFAM: arginyl-tRNA synthetase.
  
 0.973
metG
methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
  
 0.972
gltX
glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
  
 0.956
leuS
leucyl-tRNA synthetase; InterPro IPR002302:IPR015413:IPR013155:IPR002300:IPR001412; COGs: COG0495 Leucyl-tRNA synthetase; KEGG: gme:Gmet_2300 leucyl-tRNA synthetase; SPTR: Q2RKZ1 Leucyl-tRNA synthetase; TIGRFAM: leucyl-tRNA synthetase; PFAM: aminoacyl-tRNA synthetase class Ia; tRNA synthetase valyl/leucyl anticodon-binding; tRNA synthetase class I (M); Belongs to the class-I aminoacyl-tRNA synthetase family.
 
 0.952
SMB94007.1
Undecaprenyl pyrophosphate synthetase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
  
    0.922
glnS
KEGG: sfu:Sfum_3516 glutaminyl-tRNA synthetase; SPTR: Q0TTG1 Glutaminyl-tRNA synthetase; PFAM: Glutamyl/glutaminyl-tRNA synthetase, class Ic, catalytic domain; Glutamyl/glutaminyl-tRNA synthetase, class Ic, anti-codon binding domain; PRIAM: Glutamine--tRNA ligase; TIGRFAM: glutaminyl-tRNA synthetase; InterPro IPR020060:IPR020059:IPR020058:IPR001412:IPR004514; COGs: COG0008 Glutamyl- and glutaminyl-tRNA synthetase.
  
 0.921
SMB94034.1
Regulator of sigma E protease; InterPro IPR008915:IPR001478:IPR006025:IPR004387; COGs: COG0750 membrane-associated Zn-dependent protease 1; KEGG: dol:Dole_0481 putative membrane-associated zinc metalloprotease; SPTR: A1HMZ8 Putative membrane-associated zinc metalloprotease; SMART: PDZ/DHR/GLGF domain protein; PFAM: peptidase M50; TIGRFAM: membrane-associated zinc metalloprotease.
  
    0.913
dxr
1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family.
  
    0.899
lysS
lysyl-tRNA synthetase, class II; InterPro IPR018149:IPR004364:IPR004365:IPR006195:IPR002313; COGs: COG1190 Lysyl-tRNA synthetase (class II); KEGG: gme:Gmet_2360 lysyl-tRNA synthetase, class-2; SPTR: Q9KGG4 Lysyl-tRNA synthetase; PFAM: tRNA synthetase class II (D K and N); nucleic acid binding OB-fold tRNA/helicase-type; TIGRFAM: lysyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family.
  
 0.888
Your Current Organism:
Desulfonispora thiosulfatigenes
NCBI taxonomy Id: 656914
Other names: D. thiosulfatigenes DSM 11270, Desulfonispora thiosulfatigenes DSM 11270, Desulfonispora thiosulfatigenes str. DSM 11270, Desulfonispora thiosulfatigenes strain DSM 11270
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