STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
polCDNA polymerase-3 subunit alpha; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (1241 aa)    
Predicted Functional Partners:
SMB87498.1
DNA polymerase-3 subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of re [...]
    
 0.879
proS
prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...]
  
    0.792
mutL
DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
     
 0.787
SMB90832.1
DNA polymerase III, delta subunit; InterPro IPR010372:IPR002052:IPR005790; COGs: COG1466 DNA polymerase III delta subunit; KEGG: geo:Geob_2173 DNA polymerase III, delta subunit; SPTR: P54459 Uncharacterized protein yqeN; PFAM: DNA polymerase III delta; TIGRFAM: DNA polymerase III, delta subunit.
    
 0.779
SMB86946.1
DNA polymerase III, delta prime subunit; InterPro IPR003593:IPR004622; COGs: COG2812 DNA polymerase III gamma/tau subunits; KEGG: pca:Pcar_1692 DNA polymerase III, gamma/tau subunits; SPTR: P37540 DNA polymerase III subunit delta'; SMART: AAA ATPase; PRIAM: DNA-directed DNA polymerase; TIGRFAM: DNA polymerase III, delta prime subunit.
   
 0.772
SMB83070.1
DNA polymerase III catalytic subunit, DnaE type; InterPro IPR011708:IPR004013:IPR004365:IPR003141:IPR004805; COGs: COG0587 DNA polymerase III alpha subunit; KEGG: gur:Gura_2507 DNA polymerase III, alpha subunit; SPTR: A1HPG9 DNA polymerase III, alpha subunit; SMART: phosphoesterase PHP domain protein; PFAM: DNA polymerase III alpha subunit; PHP domain protein; nucleic acid binding OB-fold tRNA/helicase-type; TIGRFAM: DNA polymerase III, alpha subunit.
    
0.770
dnaX
DNA polymerase III, subunit gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
  
 0.766
SMB94049.1
Putative Mg2+ transporter-C (MgtC) family protein; InterPro IPR003416; COGs: COG1285 membrane protein; KEGG: gme:Gmet_1981 MgtC/SapB transporter; SPTR: A1HSR5 MgtC/SapB transporter; PFAM: MgtC/SapB transporter.
       0.758
uvrA
Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.
      
 0.747
nusA
NusA antitermination factor; Participates in both transcription termination and antitermination.
 
    0.746
Your Current Organism:
Desulfonispora thiosulfatigenes
NCBI taxonomy Id: 656914
Other names: D. thiosulfatigenes DSM 11270, Desulfonispora thiosulfatigenes DSM 11270, Desulfonispora thiosulfatigenes str. DSM 11270, Desulfonispora thiosulfatigenes strain DSM 11270
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