STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
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[Homology]
Score
hemCHydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (306 aa)    
Predicted Functional Partners:
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
  
 0.999
SMB94180.1
uroporphyrinogen-III synthase; InterPro IPR000878:IPR003754:IPR003043:IPR006366; COGs: COG0007 Uroporphyrinogen-III methylase; KEGG: dal:Dalk_4009 uroporphyrin-III C-methyltransferase; SPTR: A1HSI5 Uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Uroporphyrinogen III synthase HEM4; TIGRFAM: uroporphyrin-III C-methyltransferase.
 0.999
SMB94188.1
Porphobilinogen synthase; COGs: COG0113 Delta-aminolevulinic acid dehydratase; KEGG: gur:Gura_0347 delta-aminolevulinic acid dehydratase; SPTR: A2U8Q1 Delta-aminolevulinic acid dehydratase; InterPro IPR001731; PFAM: delta-aminolevulinic acid dehydratase; PRIAM: Porphobilinogen synthase; Belongs to the ALAD family.
 
 0.998
SMB94165.1
InterPro IPR010916:IPR006367; COGs: COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain); KEGG: dal:Dalk_3436 siroheme synthase; SPTR: A1HSI2 Siroheme synthase; PRIAM: Precorrin-2 dehydrogenase; TIGRFAM: siroheme synthase.
 
 0.996
hemL
InterPro IPR005814:IPR004639; COGs: COG0001 Glutamate-1-semialdehyde aminotransferase; KEGG: gur:Gura_4245 glutamate-1-semialdehyde aminotransferase; SPTR: Q2RJ31 Glutamate-1-semialdehyde 2,1-aminomutase; PFAM: aminotransferase class-III; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase.
  
 0.992
SMB94162.1
Heptaprenyl diphosphate synthase; InterPro IPR000092; COGs: COG0142 Geranylgeranyl pyrophosphate synthase; KEGG: cbs:COXBURSA331_A0492 polyprenyl synthetase family protein; SPTR: A3IEH9 HepT; PFAM: Polyprenyl synthetase; PRIAM: Trans-hexaprenyltranstransferase; Belongs to the FPP/GGPP synthase family.
  
  
 0.899
SMB91649.1
Sirohydrochlorin cobaltochelatase; InterPro IPR010388; COGs: COG4822 Cobalamin biosynthesis protein CbiK Co2+ chelatase; KEGG: plu:plu2989 cobalt chelatase; SPTR: A5KJB1 Putative uncharacterized protein; PFAM: anaerobic cobalt chelatase; PRIAM: Sirohydrochlorin cobaltochelatase.
   
 0.765
SMB94203.1
Putative heme d1 biosynthesis radical SAM protein NirJ2; InterPro IPR007197:IPR006638; COGs: COG0535 Fe-S oxidoreductase; KEGG: dol:Dole_1223 radical SAM domain-containing protein; SPTR: A1HQU1 Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; PFAM: Radical SAM domain protein.
     
 0.754
SMB94157.1
Hypothetical protein; KEGG: bfl:Bfl092 octaprenyl-diphosphate synthase.
  
  
 0.629
xseB
Exodeoxyribonuclease VII small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family.
   
    0.616
Your Current Organism:
Desulfonispora thiosulfatigenes
NCBI taxonomy Id: 656914
Other names: D. thiosulfatigenes DSM 11270, Desulfonispora thiosulfatigenes DSM 11270, Desulfonispora thiosulfatigenes str. DSM 11270, Desulfonispora thiosulfatigenes strain DSM 11270
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