STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (176 aa)    
Predicted Functional Partners:
aroB
3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
 
 0.998
aroA
3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
 
 0.995
aroE
Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
 
 0.992
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
 
 
 0.931
SMB90585.1
Chorismate mutase; InterPro IPR001086:IPR002912; COGs: COG0077 Prephenate dehydratase; KEGG: sfu:Sfum_3724 phospho-2-dehydro-3-deoxyheptonate aldolase; SPTR: A9A5Y5 Prephenate dehydratase; PFAM: prephenate dehydratase; amino acid-binding ACT domain protein; PRIAM: Chorismate mutase.
  
 
 0.920
aroQ
3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family.
  
 0.914
SMB89207.1
Prephenate dehydrogenase; InterPro IPR003099:IPR002912:IPR001732; COGs: COG0287 Prephenate dehydrogenase; KEGG: pca:Pcar_1886 cyclohexadienyl/prephenate dehydrogenase; SPTR: A2RH56 Prephenate dehydrogenase; PFAM: Prephenate dehydrogenase; amino acid-binding ACT domain protein; UDP-glucose/GDP-mannose dehydrogenase; PRIAM: Prephenate dehydrogenase.
 
 
 0.720
SMB94695.1
Type IV pilus assembly protein PilB; InterPro IPR001482:IPR003593; COGs: COG2804 Type II secretory pathway ATPase PulE/Tfp pilus assembly pathway ATPase PilB; KEGG: dal:Dalk_5144 general secretory pathway protein E; SPTR: A1HQ24 General secretory pathway protein E; SMART: AAA ATPase; PFAM: type II secretion system protein E.
       0.674
SMB90387.1
GMP synthase (glutamine-hydrolyzing), N-terminal domain or A subunit; InterPro IPR006220:IPR011702:IPR001317:IPR000991:IPR006221; COGs: COG0512 Anthranilate/para-aminobenzoate synthase component II; KEGG: neu:NE0014 anthranilate synthase component II; SPTR: Q08654 Anthranilate synthase component II; PFAM: glutamine amidotransferase class-I; TIGRFAM: glutamine amidotransferase of anthranilate synthase.
    
 0.605
SMB89185.1
3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; InterPro IPR006218:IPR006268; COGs: COG2876 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; KEGG: sat:SYN_01940 phospho-2-dehydro-3-deoxyheptanoate aldolase; SPTR: A3EWC3 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase; PFAM: DAHP synthetase I/KDSA; PRIAM: 3-deoxy-7-phosphoheptulonate synthase; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase.
 
 
 0.535
Your Current Organism:
Desulfonispora thiosulfatigenes
NCBI taxonomy Id: 656914
Other names: D. thiosulfatigenes DSM 11270, Desulfonispora thiosulfatigenes DSM 11270, Desulfonispora thiosulfatigenes str. DSM 11270, Desulfonispora thiosulfatigenes strain DSM 11270
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