STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ruvBHolliday junction DNA helicase subunit RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (332 aa)    
Predicted Functional Partners:
ruvA
Holliday junction DNA helicase subunit RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.
 
 
 0.999
ruvC
Holliday junction endonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.
 
 
 0.985
queA
S-adenosylmethionine--tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
  
  
 0.903
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
 
   
 0.732
SMB82259.1
CheR methyltransferase, SAM binding domain; InterPro IPR000780; COGs: COG1352 Methylase of chemotaxis methyl-accepting protein; KEGG: bra:BRADO2290 putative chemotaxis protein methyltransferase; SPTR: A1HMK5 MCP methyltransferase, CheR-type; SMART: MCP methyltransferase CheR-type; PFAM: MCP methyltransferase CheR-type.
    
   0.708
SMB82263.1
CheR methyltransferase, all-alpha domain; InterPro IPR000780; COGs: COG1352 Methylase of chemotaxis methyl-accepting protein; KEGG: pca:Pcar_2491 methylase of chemotaxis methyl-accepting proteins, CheR-like; SPTR: Q9KCB8 Chemotaxis protein methyltransferase.
    
   0.708
tgt
tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...]
  
    0.668
SMB95741.1
DNA-binding regulatory protein, YebC/PmpR family; InterPro IPR002876; COGs: COG0217 conserved hypothetical protein; KEGG: dps:DP2908 hypothetical protein; SPTR: B0TF65 UPF0082 protein Helmi_17570; PFAM: protein of unknown function DUF28.
 
   
 0.641
cinA
Nicotinamide-nucleotide amidase; InterPro IPR001453:IPR008136:IPR008135; COGs: COG1058 nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA; KEGG: dds:Ddes_1466 competence/damage-inducible protein CinA; SPTR: A6M320 Putative competence-damage inducible protein; PFAM: CinA domain protein; molybdopterin binding domain; TIGRFAM: competence/damage-inducible protein CinA.
  
  
 0.640
SMB95738.1
Hypothetical protein.
       0.627
Your Current Organism:
Desulfonispora thiosulfatigenes
NCBI taxonomy Id: 656914
Other names: D. thiosulfatigenes DSM 11270, Desulfonispora thiosulfatigenes DSM 11270, Desulfonispora thiosulfatigenes str. DSM 11270, Desulfonispora thiosulfatigenes strain DSM 11270
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