STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMB89742.1L-serine ammonia-lyase; InterPro IPR005130:IPR004642; COGs: COG1760 L-serine deaminase; KEGG: abb:ABBFA_002203 L-serine ammonia-lyase; SPTR: A1HMG1 L-serine dehydratase, iron-sulfur-dependent, alpha subunit; PFAM: serine dehydratase alpha chain; PRIAM: L-serine ammonia-lyase; TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, alpha subunit. (294 aa)    
Predicted Functional Partners:
SMB89740.1
L-serine ammonia-lyase; InterPro IPR005131:IPR002912:IPR004643; COGs: COG1760 L-serine deaminase; KEGG: ppw:PputW619_3319 L-serine ammonia-lyase; SPTR: A3I4A8 L-serine dehydratase beta subunit; PFAM: serine dehydratase beta chain; amino acid-binding ACT domain protein; PRIAM: L-serine ammonia-lyase; TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, beta subunit.
 
 0.999
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.886
thrB
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
  
 
 0.749
SMB94486.1
Homoserine dehydrogenase; InterPro IPR001342:IPR002912:IPR005106:IPR019811; COGs: COG0460 Homoserine dehydrogenase; KEGG: gme:Gmet_1629 homoserine dehydrogenase; SPTR: A5KQ25 Homoserine dehydrogenase; PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding; PRIAM: Homoserine dehydrogenase.
   
 
  0.746
SMB96250.1
Alpha-ribazole phosphatase; InterPro IPR003094:IPR013078; COGs: COG0406 Fructose-2 6-bisphosphatase; KEGG: lch:Lcho_3955 phosphoglycerate mutase; SPTR: A1HPV8 Phosphoglycerate mutase; PFAM: Phosphoglycerate mutase.
  
 
  0.745
SMB84435.1
InterPro IPR001451:IPR005881; COGs: COG1045 Serine acetyltransferase; KEGG: gur:Gura_1495 serine O-acetyltransferase; SPTR: A1HTI0 Serine O-acetyltransferase; TIGRFAM: serine O-acetyltransferase.
     
 0.737
SMB87452.1
Aspartate aminotransferase; InterPro IPR000192; COGs: COG0075 Serine-pyruvate aminotransferase/ aspartate aminotransferase; KEGG: bpt:Bpet4350 serine-glyoxylate aminotransferase-related; SPTR: A1HUC4 Serine--glyoxylate transaminase; PFAM: aminotransferase class V.
    
 0.735
trpA
Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
   
 
 0.734
metAA
Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family.
     
 0.730
SMB96346.1
Lactoylglutathione lyase; InterPro IPR004360; KEGG: dat:HRM2_23730 LguL; SPTR: A5KJA5 Putative uncharacterized protein; PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase.
   
 
  0.729
Your Current Organism:
Desulfonispora thiosulfatigenes
NCBI taxonomy Id: 656914
Other names: D. thiosulfatigenes DSM 11270, Desulfonispora thiosulfatigenes DSM 11270, Desulfonispora thiosulfatigenes str. DSM 11270, Desulfonispora thiosulfatigenes strain DSM 11270
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