STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMB83070.1DNA polymerase III catalytic subunit, DnaE type; InterPro IPR011708:IPR004013:IPR004365:IPR003141:IPR004805; COGs: COG0587 DNA polymerase III alpha subunit; KEGG: gur:Gura_2507 DNA polymerase III, alpha subunit; SPTR: A1HPG9 DNA polymerase III, alpha subunit; SMART: phosphoesterase PHP domain protein; PFAM: DNA polymerase III alpha subunit; PHP domain protein; nucleic acid binding OB-fold tRNA/helicase-type; TIGRFAM: DNA polymerase III, alpha subunit. (1154 aa)    
Predicted Functional Partners:
SMB87498.1
DNA polymerase-3 subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of re [...]
    
 0.975
SMB90832.1
DNA polymerase III, delta subunit; InterPro IPR010372:IPR002052:IPR005790; COGs: COG1466 DNA polymerase III delta subunit; KEGG: geo:Geob_2173 DNA polymerase III, delta subunit; SPTR: P54459 Uncharacterized protein yqeN; PFAM: DNA polymerase III delta; TIGRFAM: DNA polymerase III, delta subunit.
  
 0.974
SMB86946.1
DNA polymerase III, delta prime subunit; InterPro IPR003593:IPR004622; COGs: COG2812 DNA polymerase III gamma/tau subunits; KEGG: pca:Pcar_1692 DNA polymerase III, gamma/tau subunits; SPTR: P37540 DNA polymerase III subunit delta'; SMART: AAA ATPase; PRIAM: DNA-directed DNA polymerase; TIGRFAM: DNA polymerase III, delta prime subunit.
 
 0.956
dnaX
DNA polymerase III, subunit gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
 
 0.948
SMB87112.1
InterPro IPR019841; COGs: COG2812 DNA polymerase III gamma/tau subunits; KEGG: glo:Glov_0365 DNA polymerase III, subunits gamma and tau; SPTR: P09122 DNA polymerase III subunit gamma/tau.
  
 0.937
SMB95481.1
Single-strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.
 
 
 0.902
SMB87695.1
Single-strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.
 
 
 0.901
dinG
ATP-dependent DNA helicase DinG; 3'-5' exonuclease.
 
 
 0.878
dinB
DNA polymerase-4; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
  
 0.812
polC
DNA polymerase-3 subunit alpha; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
    
0.770
Your Current Organism:
Desulfonispora thiosulfatigenes
NCBI taxonomy Id: 656914
Other names: D. thiosulfatigenes DSM 11270, Desulfonispora thiosulfatigenes DSM 11270, Desulfonispora thiosulfatigenes str. DSM 11270, Desulfonispora thiosulfatigenes strain DSM 11270
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.