STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
folDMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (281 aa)    
Predicted Functional Partners:
fhs
Formate-tetrahydrofolate ligase; InterPro IPR000559; COGs: COG2759 Formyltetrahydrofolate synthetase; KEGG: apa:APP7_0543 formate--tetrahydrofolate ligase; SPTR: Q24ZZ8 Formate--tetrahydrofolate ligase 2; PFAM: formate-tetrahydrofolate ligase FTHFS; PRIAM: Formate--tetrahydrofolate ligase.
 
 
 0.995
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
 
 0.967
xseA
Exodeoxyribonuclease VII large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family.
    0.957
fmt
methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family.
 
 
 0.941
purD
Phosphoribosylamine--glycine ligase; InterPro IPR003135:IPR003806:IPR000115:IPR011761; COGs: COG0151 Phosphoribosylamine-glycine ligase; KEGG: gsu:GSU0610 phosphoribosylamine--glycine ligase; SPTR: A1HSW5 Phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase; protein of unknown function DUF201; ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; PRIAM: Phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine/glycine ligase; Belongs to the GARS family.
 
 
 0.936
purN
Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
 
 
 0.930
purH
IMP cyclohydrolase; InterPro IPR011607:IPR013982:IPR002695; COGs: COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); KEGG: aci:ACIAD2447 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; SPTR: Q0AW31 Bifunctional purine biosynthesis protein purH; SMART: AICARFT/IMPCHase bienzyme formylation region; PFAM: AICARFT/IMPCHase bienzyme formylation region; MGS domain protein; PRIAM: IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase.
 
 
 0.930
SMB86768.1
InterPro IPR003171; COGs: COG0685 5 10-methylenetetrahydrofolate reductase; KEGG: gme:Gmet_1160 methylenetetrahydrofolate reductase; SPTR: Q8TKA0 5,10-methylenetetrahydrofolate reductase (FADH); PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.
    
 0.903
SMB79105.1
Isocitrate dehydrogenase (NADP); InterPro IPR001804:IPR019818:IPR004790; COGs: COG0538 Isocitrate dehydrogenase; KEGG: dps:DP0778 isocitrate dehydrogenase; SPTR: A5KQ84 Putative uncharacterized protein; PFAM: isocitrate/isopropylmalate dehydrogenase; PRIAM: Isocitrate dehydrogenase (NADP(+)); TIGRFAM: isocitrate dehydrogenase, NADP-dependent; Belongs to the isocitrate and isopropylmalate dehydrogenases family.
    
 0.899
gcvT
Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine.
  
 
 0.892
Your Current Organism:
Desulfonispora thiosulfatigenes
NCBI taxonomy Id: 656914
Other names: D. thiosulfatigenes DSM 11270, Desulfonispora thiosulfatigenes DSM 11270, Desulfonispora thiosulfatigenes str. DSM 11270, Desulfonispora thiosulfatigenes strain DSM 11270
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