STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
dnaJMolecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] (386 aa)    
Predicted Functional Partners:
dnaK
Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
 0.999
grpE
Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...]
 
 
 0.992
htpG
Molecular chaperone HtpG; Molecular chaperone. Has ATPase activity.
  
 0.985
prmA
Ribosomal protein L11 methyltransferase; Methylates ribosomal protein L11; Belongs to the methyltransferase superfamily. PrmA family.
 
  
 0.959
SMB83330.1
Pyruvate-ferredoxin/flavodoxin oxidoreductase; InterPro IPR001450:IPR019752:IPR019456:IPR002880:IPR017900:IPR0118 95; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; KEGG: dvl:Dvul_0348 pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein; SPTR: A1HPH8 Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate/ketoisovalerate oxidoreductase; 4Fe-4S ferredoxin iron-sulfur binding domain protein; Pyruvate-flavodoxin oxidoreduct [...]
   
 
 0.936
hrcA
Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons.
  
  
 0.915
SMB90910.1
16S rRNA (uracil1498-N3)-methyltransferase; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.
 
   0.913
SMB90879.1
Chaperonin GroEL (HSP60 family); InterPro IPR017998:IPR001844:IPR002423:IPR002194; COGs: COG0459 Chaperonin GroEL (HSP60 family); KEGG: t-complex protein 1, gamma subunit, putative; K09495 T-complex protein 1 subunit gamma; SPTR: A1HR08 Chaperonin Cpn60/TCP-1; PFAM: chaperonin Cpn60/TCP-1.
  
 0.906
SMB90917.1
Threonylcarbamoyladenosine tRNA methylthiotransferase MtaB; InterPro IPR007197:IPR002792:IPR013848:IPR006638:IPR005839:IPR0064 67; COGs: COG0621 2-methylthioadenine synthetase; KEGG: sat:SYN_00797 tRNA 2-methylthioadenosine synthase -like protein; SPTR: A1HR14 RNA modification enzyme, MiaB family; SMART: Elongator protein 3/MiaB/NifB; PFAM: Protein of unknown function UPF0004; Radical SAM domain protein; deoxyribonuclease/rho motif-related TRAM; TIGRFAM: RNA modification enzyme, MiaB family; MiaB-like tRNA modifying enzyme.
  
 
 0.885
SMB83517.1
4Fe-4S dicluster domain-containing protein; InterPro IPR001450:IPR017900; KEGG: dal:Dalk_1151 4Fe-4S ferredoxin iron-sulfur binding domain protein; SPTR: Q9P9J2 Polyferredoxin; PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein.
   
 
 0.877
Your Current Organism:
Desulfonispora thiosulfatigenes
NCBI taxonomy Id: 656914
Other names: D. thiosulfatigenes DSM 11270, Desulfonispora thiosulfatigenes DSM 11270, Desulfonispora thiosulfatigenes str. DSM 11270, Desulfonispora thiosulfatigenes strain DSM 11270
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