node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SMB83330.1 | SMB83448.1 | SAMN00017405_1028 | SAMN00017405_1040 | Pyruvate-ferredoxin/flavodoxin oxidoreductase; InterPro IPR001450:IPR019752:IPR019456:IPR002880:IPR017900:IPR0118 95; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; KEGG: dvl:Dvul_0348 pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein; SPTR: A1HPH8 Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate/ketoisovalerate oxidoreductase; 4Fe-4S ferredoxin iron-sulfur binding domain protein; Pyruvate-flavodoxin oxidoreduct [...] | DNA topoisomerase III; InterPro IPR000380:IPR013497:IPR013498:IPR003602; COGs: COG0550 Topoisomerase IA; KEGG: hso:HS_1737 DNA topoisomerase III; SPTR: Q6HP19 DNA topoisomerase 3; SMART: DNA topoisomerase I DNA-binding; PFAM: DNA topoisomerase type IA central domain protein; DNA topoisomerase type IA zn finger domain protein; PRIAM: DNA topoisomerase. | 0.934 |
SMB83330.1 | SMB96346.1 | SAMN00017405_1028 | SAMN00017405_1509 | Pyruvate-ferredoxin/flavodoxin oxidoreductase; InterPro IPR001450:IPR019752:IPR019456:IPR002880:IPR017900:IPR0118 95; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; KEGG: dvl:Dvul_0348 pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein; SPTR: A1HPH8 Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate/ketoisovalerate oxidoreductase; 4Fe-4S ferredoxin iron-sulfur binding domain protein; Pyruvate-flavodoxin oxidoreduct [...] | Lactoylglutathione lyase; InterPro IPR004360; KEGG: dat:HRM2_23730 LguL; SPTR: A5KJA5 Putative uncharacterized protein; PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase. | 0.967 |
SMB83330.1 | deoC | SAMN00017405_1028 | SAMN00017405_1691 | Pyruvate-ferredoxin/flavodoxin oxidoreductase; InterPro IPR001450:IPR019752:IPR019456:IPR002880:IPR017900:IPR0118 95; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; KEGG: dvl:Dvul_0348 pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein; SPTR: A1HPH8 Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate/ketoisovalerate oxidoreductase; 4Fe-4S ferredoxin iron-sulfur binding domain protein; Pyruvate-flavodoxin oxidoreduct [...] | Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. | 0.894 |
SMB83330.1 | dnaX | SAMN00017405_1028 | SAMN00017405_1236 | Pyruvate-ferredoxin/flavodoxin oxidoreductase; InterPro IPR001450:IPR019752:IPR019456:IPR002880:IPR017900:IPR0118 95; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; KEGG: dvl:Dvul_0348 pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein; SPTR: A1HPH8 Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate/ketoisovalerate oxidoreductase; 4Fe-4S ferredoxin iron-sulfur binding domain protein; Pyruvate-flavodoxin oxidoreduct [...] | DNA polymerase III, subunit gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | 0.445 |
SMB83330.1 | polA | SAMN00017405_1028 | SAMN00017405_2122 | Pyruvate-ferredoxin/flavodoxin oxidoreductase; InterPro IPR001450:IPR019752:IPR019456:IPR002880:IPR017900:IPR0118 95; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; KEGG: dvl:Dvul_0348 pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein; SPTR: A1HPH8 Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate/ketoisovalerate oxidoreductase; 4Fe-4S ferredoxin iron-sulfur binding domain protein; Pyruvate-flavodoxin oxidoreduct [...] | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.401 |
SMB83330.1 | rnhA | SAMN00017405_1028 | SAMN00017405_1510 | Pyruvate-ferredoxin/flavodoxin oxidoreductase; InterPro IPR001450:IPR019752:IPR019456:IPR002880:IPR017900:IPR0118 95; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; KEGG: dvl:Dvul_0348 pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein; SPTR: A1HPH8 Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate/ketoisovalerate oxidoreductase; 4Fe-4S ferredoxin iron-sulfur binding domain protein; Pyruvate-flavodoxin oxidoreduct [...] | RNase HI; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.896 |
SMB83330.1 | rnhB | SAMN00017405_1028 | SAMN00017405_0103 | Pyruvate-ferredoxin/flavodoxin oxidoreductase; InterPro IPR001450:IPR019752:IPR019456:IPR002880:IPR017900:IPR0118 95; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; KEGG: dvl:Dvul_0348 pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein; SPTR: A1HPH8 Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate/ketoisovalerate oxidoreductase; 4Fe-4S ferredoxin iron-sulfur binding domain protein; Pyruvate-flavodoxin oxidoreduct [...] | RNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.461 |
SMB83330.1 | topA | SAMN00017405_1028 | SAMN00017405_0122 | Pyruvate-ferredoxin/flavodoxin oxidoreductase; InterPro IPR001450:IPR019752:IPR019456:IPR002880:IPR017900:IPR0118 95; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; KEGG: dvl:Dvul_0348 pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein; SPTR: A1HPH8 Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate/ketoisovalerate oxidoreductase; 4Fe-4S ferredoxin iron-sulfur binding domain protein; Pyruvate-flavodoxin oxidoreduct [...] | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.934 |
SMB83448.1 | SMB83330.1 | SAMN00017405_1040 | SAMN00017405_1028 | DNA topoisomerase III; InterPro IPR000380:IPR013497:IPR013498:IPR003602; COGs: COG0550 Topoisomerase IA; KEGG: hso:HS_1737 DNA topoisomerase III; SPTR: Q6HP19 DNA topoisomerase 3; SMART: DNA topoisomerase I DNA-binding; PFAM: DNA topoisomerase type IA central domain protein; DNA topoisomerase type IA zn finger domain protein; PRIAM: DNA topoisomerase. | Pyruvate-ferredoxin/flavodoxin oxidoreductase; InterPro IPR001450:IPR019752:IPR019456:IPR002880:IPR017900:IPR0118 95; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; KEGG: dvl:Dvul_0348 pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein; SPTR: A1HPH8 Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate/ketoisovalerate oxidoreductase; 4Fe-4S ferredoxin iron-sulfur binding domain protein; Pyruvate-flavodoxin oxidoreduct [...] | 0.934 |
SMB83448.1 | SMB87695.1 | SAMN00017405_1040 | SAMN00017405_1745 | DNA topoisomerase III; InterPro IPR000380:IPR013497:IPR013498:IPR003602; COGs: COG0550 Topoisomerase IA; KEGG: hso:HS_1737 DNA topoisomerase III; SPTR: Q6HP19 DNA topoisomerase 3; SMART: DNA topoisomerase I DNA-binding; PFAM: DNA topoisomerase type IA central domain protein; DNA topoisomerase type IA zn finger domain protein; PRIAM: DNA topoisomerase. | Single-strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. | 0.891 |
SMB83448.1 | SMB95481.1 | SAMN00017405_1040 | SAMN00017405_0413 | DNA topoisomerase III; InterPro IPR000380:IPR013497:IPR013498:IPR003602; COGs: COG0550 Topoisomerase IA; KEGG: hso:HS_1737 DNA topoisomerase III; SPTR: Q6HP19 DNA topoisomerase 3; SMART: DNA topoisomerase I DNA-binding; PFAM: DNA topoisomerase type IA central domain protein; DNA topoisomerase type IA zn finger domain protein; PRIAM: DNA topoisomerase. | Single-strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. | 0.891 |
SMB83448.1 | polA | SAMN00017405_1040 | SAMN00017405_2122 | DNA topoisomerase III; InterPro IPR000380:IPR013497:IPR013498:IPR003602; COGs: COG0550 Topoisomerase IA; KEGG: hso:HS_1737 DNA topoisomerase III; SPTR: Q6HP19 DNA topoisomerase 3; SMART: DNA topoisomerase I DNA-binding; PFAM: DNA topoisomerase type IA central domain protein; DNA topoisomerase type IA zn finger domain protein; PRIAM: DNA topoisomerase. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.847 |
SMB83448.1 | rnhA | SAMN00017405_1040 | SAMN00017405_1510 | DNA topoisomerase III; InterPro IPR000380:IPR013497:IPR013498:IPR003602; COGs: COG0550 Topoisomerase IA; KEGG: hso:HS_1737 DNA topoisomerase III; SPTR: Q6HP19 DNA topoisomerase 3; SMART: DNA topoisomerase I DNA-binding; PFAM: DNA topoisomerase type IA central domain protein; DNA topoisomerase type IA zn finger domain protein; PRIAM: DNA topoisomerase. | RNase HI; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.693 |
SMB87695.1 | SMB83448.1 | SAMN00017405_1745 | SAMN00017405_1040 | Single-strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. | DNA topoisomerase III; InterPro IPR000380:IPR013497:IPR013498:IPR003602; COGs: COG0550 Topoisomerase IA; KEGG: hso:HS_1737 DNA topoisomerase III; SPTR: Q6HP19 DNA topoisomerase 3; SMART: DNA topoisomerase I DNA-binding; PFAM: DNA topoisomerase type IA central domain protein; DNA topoisomerase type IA zn finger domain protein; PRIAM: DNA topoisomerase. | 0.891 |
SMB87695.1 | dnaX | SAMN00017405_1745 | SAMN00017405_1236 | Single-strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. | DNA polymerase III, subunit gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | 0.752 |
SMB87695.1 | polA | SAMN00017405_1745 | SAMN00017405_2122 | Single-strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.647 |
SMB87695.1 | rnhA | SAMN00017405_1745 | SAMN00017405_1510 | Single-strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. | RNase HI; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.714 |
SMB87695.1 | topA | SAMN00017405_1745 | SAMN00017405_0122 | Single-strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.891 |
SMB95481.1 | SMB83448.1 | SAMN00017405_0413 | SAMN00017405_1040 | Single-strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. | DNA topoisomerase III; InterPro IPR000380:IPR013497:IPR013498:IPR003602; COGs: COG0550 Topoisomerase IA; KEGG: hso:HS_1737 DNA topoisomerase III; SPTR: Q6HP19 DNA topoisomerase 3; SMART: DNA topoisomerase I DNA-binding; PFAM: DNA topoisomerase type IA central domain protein; DNA topoisomerase type IA zn finger domain protein; PRIAM: DNA topoisomerase. | 0.891 |
SMB95481.1 | dnaX | SAMN00017405_0413 | SAMN00017405_1236 | Single-strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. | DNA polymerase III, subunit gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | 0.755 |