STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMB84871.1Formate C-acetyltransferase; InterPro IPR001150:IPR004184:IPR019777:IPR005949; COGs: COG1882 Pyruvate-formate lyase; KEGG: dno:DNO_1334 pyruvate-formate lyase; SPTR: Q46266 Formate acetyltransferase; PFAM: pyruvate formate-lyase PFL; formate C-acetyltransferase glycine radical; PRIAM: Formate C-acetyltransferase; TIGRFAM: formate acetyltransferase. (744 aa)    
Predicted Functional Partners:
SMB84850.1
Pyruvate formate lyase activating enzyme; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family.
  
 0.997
SMB83330.1
Pyruvate-ferredoxin/flavodoxin oxidoreductase; InterPro IPR001450:IPR019752:IPR019456:IPR002880:IPR017900:IPR0118 95; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; KEGG: dvl:Dvul_0348 pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein; SPTR: A1HPH8 Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate/ketoisovalerate oxidoreductase; 4Fe-4S ferredoxin iron-sulfur binding domain protein; Pyruvate-flavodoxin oxidoreduct [...]
    
 0.944
SMB93584.1
Phosphotransacetylase; InterPro IPR002505:IPR004614; COGs: COG0280 Phosphotransacetylase; KEGG: ppd:Ppro_1290 phosphate acetyltransferase; SPTR: Q59330 Phosphate acetyltransferase; PFAM: phosphate acetyl/butaryl transferase; TIGRFAM: phosphate acetyltransferase.
   
 
 0.924
SMB96397.1
4Fe-4S single cluster domain-containing protein; InterPro IPR001989; KEGG: cla:Cla_0049 anaerobic ribonucleoside triphosphate reductase activating protein; SPTR: A1HS96 Anaerobic ribonucleoside-triphosphate reductase activating protein.
 
  
 0.923
SMB84626.1
Pyruvate carboxylase subunit B; InterPro IPR000891:IPR003379:IPR000089:IPR001882:IPR005776; COGs: COG5016 Pyruvate/oxaloacetate carboxyltransferase; KEGG: hch:HCH_06704 pyruvate carboxylase subunit B; SPTR: B5IWM5 Oxaloacetate decarboxylase alpha subunit; PFAM: Conserved carboxylase region; pyruvate carboxyltransferase; biotin/lipoyl attachment domain-containing protein; TIGRFAM: oxaloacetate decarboxylase alpha subunit.
     
 0.865
SMB82978.1
TIGRFAM: pyruvate kinase; InterPro IPR015793:IPR008279:IPR015794:IPR018209:IPR001697; COGs: COG0469 Pyruvate kinase; KEGG: dps:DP3116 pyruvate kinase; SPTR: P80885 Pyruvate kinase; PFAM: Pyruvate kinase barrel; PEP-utilising protein mobile region; Pyruvate kinase alpha/beta; Belongs to the pyruvate kinase family.
   
 
 0.847
SMB90274.1
Pyruvate, water dikinase; InterPro IPR008279:IPR002192; COGs: COG0574 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase; KEGG: scl:sce4177 phosphoenolpyruvate synthase; SPTR: Q466P7 Phosphoenolpyruvate synthase; PFAM: pyruvate phosphate dikinase PEP/pyruvate-binding; PEP-utilising protein mobile region; PRIAM: Pyruvate, water dikinase.
    
 0.814
SMB83517.1
4Fe-4S dicluster domain-containing protein; InterPro IPR001450:IPR017900; KEGG: dal:Dalk_1151 4Fe-4S ferredoxin iron-sulfur binding domain protein; SPTR: Q9P9J2 Polyferredoxin; PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein.
     
 0.805
SMB92300.1
Malate dehydrogenase (oxaloacetate-decarboxylating); InterPro IPR001891:IPR012302:IPR012301; COGs: COG0281 Malic enzyme; KEGG: dds:Ddes_1534 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)); SPTR: O34962 Probable NAD-dependent malic enzyme 4; PFAM: malic protein NAD-binding; malic protein domain protein; PRIAM: Malate dehydrogenase (oxaloacetate-decarboxylating).
   
 
 0.802
SMB92454.1
1,3-propanediol dehydrogenase; InterPro IPR001670:IPR018211; COGs: COG1454 Alcohol dehydrogenase class IV; KEGG: pca:Pcar_2847 alcohol dehydrogenase, class IV; SPTR: Q8TMM6 Alcohol dehydrogenase; PFAM: iron-containing alcohol dehydrogenase.
 
 
 0.796
Your Current Organism:
Desulfonispora thiosulfatigenes
NCBI taxonomy Id: 656914
Other names: D. thiosulfatigenes DSM 11270, Desulfonispora thiosulfatigenes DSM 11270, Desulfonispora thiosulfatigenes str. DSM 11270, Desulfonispora thiosulfatigenes strain DSM 11270
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.