STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (429 aa)    
Predicted Functional Partners:
SMB92572.1
Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; InterPro IPR006130:IPR002082:IPR002292:IPR006132; COGs: COG0540 Aspartate carbamoyltransferase catalytic chain; KEGG: gsu:GSU1271 aspartate carbamoyltransferase catalytic subunit; SPTR: B0TGQ3 Aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain.
 0.999
SMB92580.1
Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; InterPro IPR006130:IPR002082:IPR006131; COGs: COG0540 Aspartate carbamoyltransferase catalytic chain; KEGG: sat:SYN_01532 aspartate carbamoyltransferase; SPTR: B2A2U7 Aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; PRIAM: Aspartate carbamoyltransferase.
 
 0.999
pyrD
Dihydroorotate oxidase B, catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate.
 
 0.998
carA-2
Carbamoyl-phosphate synthase small subunit; InterPro IPR011702:IPR001317:IPR002474:IPR000991:IPR006274; COGs: COG0505 Carbamoylphosphate synthase small subunit; KEGG: pca:Pcar_1613 carbamoyl phosphate synthase small subunit; SPTR: Q8CXH8 Carbamoyl-phosphate synthase small chain; PFAM: Carbamoyl-phosphate synthase small chain; glutamine amidotransferase class-I; TIGRFAM: carbamoyl-phosphate synthase, small subunit; Belongs to the CarA family.
  
 0.996
carB-2
Carbamoyl-phosphate synthase large subunit; InterPro IPR005483:IPR003135:IPR005479:IPR003806:IPR013651:IPR0116 07:IPR005480:IPR005481:IPR011761:IPR006275; COGs: COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); KEGG: dat:HRM2_47760 CarB2; SPTR: B1I4M8 Carbamoyl-phosphate synthase large chain; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; protein of unknown function DUF201; RimK domain protein ATP-grasp; MGS domain protein; Carbamoyl-phosphate synthetase large chain oligomerisation; Carbamoyl- [...]
 
 0.996
pyrE
Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
  
 
 0.994
pyrF
Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.
 
  
 0.992
pyrK
Dihydroorotate dehydrogenase electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).
 
 
 0.987
carB
Carbamoyl-phosphate synthase large subunit; InterPro IPR005483:IPR005479:IPR003806:IPR000115:IPR011607:IPR0054 80:IPR005481:IPR011761:IPR006275; COGs: COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); KEGG: gur:Gura_1864 carbamoyl-phosphate synthase, large subunit; SPTR: A5D508 Carbamoyl-phosphate synthase large chain; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; protein of unknown function DUF201; phosphoribosylglycinamide synthetase; MGS domain protein; Carbamoyl-phosphate synthetase large chain oligomerisation; Carbamoyl-phosphate synthetase large chai [...]
 
 0.985
carA
Carbamoyl-phosphate synthase small subunit; InterPro IPR011702:IPR001317:IPR002474:IPR000991:IPR006274; COGs: COG0505 Carbamoylphosphate synthase small subunit; SPTR: Q8XHB2 Carbamoyl-phosphate synthase small chain; PFAM: Carbamoyl-phosphate synthase small chain; glutamine amidotransferase class-I; TIGRFAM: carbamoyl-phosphate synthase, small subunit; KEGG: pca:Pcar_1613 carbamoyl phosphate synthase small subunit; Belongs to the CarA family.
  
 0.983
Your Current Organism:
Desulfonispora thiosulfatigenes
NCBI taxonomy Id: 656914
Other names: D. thiosulfatigenes DSM 11270, Desulfonispora thiosulfatigenes DSM 11270, Desulfonispora thiosulfatigenes str. DSM 11270, Desulfonispora thiosulfatigenes strain DSM 11270
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