STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ribBA3,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (398 aa)    
Predicted Functional Partners:
SMB92827.1
Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
 0.999
SMB92831.1
InterPro IPR001783; COGs: COG0307 Riboflavin synthase alpha chain; KEGG: apa:APP7_0407 riboflavin synthase subunit alpha; SPTR: A1HMW3 Riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; PRIAM: Riboflavin synthase; TIGRFAM: riboflavin synthase, alpha subunit.
 0.999
ribH
6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
 
 0.999
SMB95186.1
Diguanylate cyclase (GGDEF) domain-containing protein; InterPro IPR000160:IPR006674:IPR003660:IPR003607; COGs: COG2206 HD-GYP domain; KEGG: ppr:PBPRA1970 hypothetical protein; SPTR: Q0W2L1 Putative signal transduction protein; SMART: GGDEF domain containing protein; metal-dependent phosphohydrolase HD region; histidine kinase HAMP region domain protein; PFAM: GGDEF domain containing protein; metal-dependent phosphohydrolase HD sub domain; histidine kinase HAMP region domain protein; TIGRFAM: diguanylate cyclase.
   
 0.940
SMB91545.1
2-amino-4-hydroxy-6- hydroxymethyldihydropteridinediphosphokinase; InterPro IPR000550; COGs: COG0801 7 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; KEGG: sat:SYN_02163 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HppK); SPTR: A5LYN7 Bifunctional folate synthesis protein; PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK; PRIAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase; TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase.
  
 
 0.936
SMB93428.1
Cell elongation-specific peptidoglycan biosynthesis regulator RodA; InterPro IPR001182; COGs: COG0772 Bacterial cell division membrane protein; KEGG: sat:SYN_01745 cell division protein; SPTR: A1HMW9 Cell cycle protein; PFAM: cell cycle protein; Belongs to the SEDS family.
    
 0.924
SMB80928.1
PAS domain S-box-containing protein/diguanylate cyclase (GGDEF) domain-containing protein; InterPro IPR013655:IPR000160:IPR000700:IPR000014; COGs: COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain; KEGG: pag:PLES_03351 putative sensory box protein; SPTR: A3L087 Putative uncharacterized protein; SMART: GGDEF domain containing protein; TIGRFAM: diguanylate cyclase; PAS sensor protein; PFAM: GGDEF domain containing protein; PAS fold-3 domain protein.
   
 0.920
folE
GTP cyclohydrolase I; InterPro IPR001474:IPR018234; COGs: COG0302 GTP cyclohydrolase I; KEGG: bcs:BCAN_A1090 GTP cyclohydrolase I; SPTR: B1IL94 GTP cyclohydrolase 1; PFAM: GTP cyclohydrolase I; PRIAM: GTP cyclohydrolase I; TIGRFAM: GTP cyclohydrolase I.
  
 
 0.912
tadA
tRNA-adenosine deaminase; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family.
    
 0.909
SMB79879.1
PAS domain S-box-containing protein/diguanylate cyclase (GGDEF) domain-containing protein; InterPro IPR013655:IPR000160:IPR006674:IPR013767:IPR001610:IPR0036 07:IPR000014:IPR000700; COGs: COG2206 HD-GYP domain; KEGG: pin:Ping_0273 diguanylate cyclase with PAS/PAC sensor; SPTR: A0YVN1 PleD-like protein; SMART: GGDEF domain containing protein; PAC repeat-containing protein; metal-dependent phosphohydrolase HD region; PAS domain containing protein; TIGRFAM: diguanylate cyclase; PAS sensor protein; PFAM: GGDEF domain containing protein; PAS fold-3 domain protein; metal-dependent phosphohyd [...]
   
 0.904
Your Current Organism:
Desulfonispora thiosulfatigenes
NCBI taxonomy Id: 656914
Other names: D. thiosulfatigenes DSM 11270, Desulfonispora thiosulfatigenes DSM 11270, Desulfonispora thiosulfatigenes str. DSM 11270, Desulfonispora thiosulfatigenes strain DSM 11270
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