STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
mutMDNA-(apurinic or apyrimidinic site) lyase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (278 aa)    
Predicted Functional Partners:
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
  
  
 0.999
coaE
dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.
 
  
 0.987
SMB92930.1
Putative sporulation protein YtaF; Probably functions as a manganese efflux pump.
 
    0.803
uvrC
Excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
  
 
 0.732
nth
DNA-(apurinic or apyrimidinic site) lyase; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
   
  
 0.689
SMB80000.1
Protein of unknown function; KEGG: sde:Sde_1829 methionine sulfoxide reductase A; SPTR: A2U5Q5 Methionine sulfoxide reductase A.
  
 
 0.609
SMB88587.1
DNA polymerase; InterPro IPR001098:IPR019760; COGs: COG0749 DNA polymerase I - 3'-5' exonuclease and polymerase domains; KEGG: ecr:ECIAI1_2664 putative DNA polymerase from bacteriophage origin; SPTR: P06225 DNA polymerase; SMART: DNA-directed DNA polymerase; PFAM: DNA-directed DNA polymerase.
  
  
 0.600
dinG
ATP-dependent DNA helicase DinG; 3'-5' exonuclease.
  
  
 0.581
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
     
 0.577
SMB92936.1
InterPro IPR008258; COGs: COG0741 Soluble lytic murein transglycosylase and related regulatory protein (some contain LysM/invasin domains); KEGG: gme:Gmet_1377 lytic transglycosylase, catalytic; SPTR: A1HPM6 Lytic transglycosylase, catalytic; PFAM: Lytic transglycosylase catalytic.
  
    0.498
Your Current Organism:
Desulfonispora thiosulfatigenes
NCBI taxonomy Id: 656914
Other names: D. thiosulfatigenes DSM 11270, Desulfonispora thiosulfatigenes DSM 11270, Desulfonispora thiosulfatigenes str. DSM 11270, Desulfonispora thiosulfatigenes strain DSM 11270
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.