STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KP79_PYT18429DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (852 aa)    
Predicted Functional Partners:
KP79_PYT09538
Fanconi anemia group M protein.
   
 0.999
KP79_PYT05270
RecQ-mediated genome instability protein 1.
    
 0.985
KP79_PYT13042
Tudor domain-containing protein 3.
    
 0.983
KP79_PYT19695
Replication protein A 14 kDa subunit.
    
 0.982
KP79_PYT22799
ATP-dependent DNA helicase RecS.
  
 0.973
KP79_PYT19025
Werner syndrome ATP-dependent helicase-like.
  
 0.973
KP79_PYT00395
Werner syndrome ATP-dependent helicase.
  
 0.973
KP79_PYT25386
Werner syndrome ATP-dependent helicase.
  
 0.973
KP79_PYT07884
Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
    
 0.970
KP79_PYT08672
RecQ-mediated genome instability protein 2.
    
 0.967
Your Current Organism:
Mizuhopecten yessoensis
NCBI taxonomy Id: 6573
Other names: M. yessoensis, Patinopecten yessoensis, Patiopecten yessoensis, Yesso scallop, ezo giant scallop
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