| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| KP79_PYT05270 | KP79_PYT05462 | A0A210QXZ2 | A0A210PTA2 | RecQ-mediated genome instability protein 1. | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | 0.999 |
| KP79_PYT05270 | KP79_PYT05855 | A0A210QXZ2 | A0A210QV46 | RecQ-mediated genome instability protein 1. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.685 |
| KP79_PYT05270 | KP79_PYT07884 | A0A210QXZ2 | A0A210PMD2 | RecQ-mediated genome instability protein 1. | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.996 |
| KP79_PYT05270 | KP79_PYT09109 | A0A210QXZ2 | A0A210PNJ6 | RecQ-mediated genome instability protein 1. | Replication protein A 32 kDa subunit. | 0.984 |
| KP79_PYT05270 | KP79_PYT09538 | A0A210QXZ2 | A0A210QQ07 | RecQ-mediated genome instability protein 1. | Fanconi anemia group M protein. | 0.998 |
| KP79_PYT05270 | KP79_PYT10258 | A0A210QXZ2 | A0A210PYY6 | RecQ-mediated genome instability protein 1. | DNA repair protein RAD51-like A; Belongs to the RecA family. | 0.903 |
| KP79_PYT05270 | KP79_PYT11275 | A0A210QXZ2 | A0A210Q925 | RecQ-mediated genome instability protein 1. | DNA repair protein RAD52-like. | 0.827 |
| KP79_PYT05270 | KP79_PYT11706 | A0A210QXZ2 | A0A210QSC5 | RecQ-mediated genome instability protein 1. | ATR-interacting protein. | 0.623 |
| KP79_PYT05270 | KP79_PYT19695 | A0A210QXZ2 | A0A210PU78 | RecQ-mediated genome instability protein 1. | Replication protein A 14 kDa subunit. | 0.996 |
| KP79_PYT05270 | KP79_PYT23822 | A0A210QXZ2 | A0A210R1R7 | RecQ-mediated genome instability protein 1. | Replication factor C subunit 1. | 0.522 |
| KP79_PYT05462 | KP79_PYT05270 | A0A210PTA2 | A0A210QXZ2 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | RecQ-mediated genome instability protein 1. | 0.999 |
| KP79_PYT05462 | KP79_PYT05855 | A0A210PTA2 | A0A210QV46 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.840 |
| KP79_PYT05462 | KP79_PYT07884 | A0A210PTA2 | A0A210PMD2 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.997 |
| KP79_PYT05462 | KP79_PYT09109 | A0A210PTA2 | A0A210PNJ6 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | Replication protein A 32 kDa subunit. | 0.987 |
| KP79_PYT05462 | KP79_PYT09538 | A0A210PTA2 | A0A210QQ07 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | Fanconi anemia group M protein. | 0.998 |
| KP79_PYT05462 | KP79_PYT10258 | A0A210PTA2 | A0A210PYY6 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | DNA repair protein RAD51-like A; Belongs to the RecA family. | 0.983 |
| KP79_PYT05462 | KP79_PYT11275 | A0A210PTA2 | A0A210Q925 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | DNA repair protein RAD52-like. | 0.942 |
| KP79_PYT05462 | KP79_PYT11706 | A0A210PTA2 | A0A210QSC5 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | ATR-interacting protein. | 0.668 |
| KP79_PYT05462 | KP79_PYT19695 | A0A210PTA2 | A0A210PU78 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | Replication protein A 14 kDa subunit. | 0.996 |
| KP79_PYT05462 | KP79_PYT23822 | A0A210PTA2 | A0A210R1R7 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | Replication factor C subunit 1. | 0.770 |
