node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KP79_PYT06880 | KP79_PYT07321 | A0A210QUN1 | A0A210QB18 | Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. | Tyrosine--tRNA ligase. | 0.772 |
KP79_PYT06880 | KP79_PYT08117 | A0A210QUN1 | A0A210QBT4 | Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. | tRNA threonylcarbamoyladenosine biosynthesis protein YwlC. | 0.743 |
KP79_PYT06880 | KP79_PYT09716 | A0A210QUN1 | A0A210QCL0 | Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. | Bifunctional glutamate/proline--tRNA ligase. | 0.834 |
KP79_PYT06880 | KP79_PYT14261 | A0A210QUN1 | A0A210PN87 | Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. | Probable tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. | 0.545 |
KP79_PYT06880 | KP79_PYT15370 | A0A210QUN1 | A0A210QZ91 | Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. | tRNA modification GTPase GTPBP3, mitochondrial. | 0.741 |
KP79_PYT06880 | KP79_PYT17872 | A0A210QUN1 | A0A210PIR9 | Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. | tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family. | 0.843 |
KP79_PYT06880 | KP79_PYT19700 | A0A210QUN1 | A0A210PU35 | Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. | Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance. | 0.541 |
KP79_PYT06880 | KP79_PYT22900 | A0A210QUN1 | A0A210QLL5 | Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. | Methionyl-tRNA formyltransferase, mitochondrial. | 0.761 |
KP79_PYT07321 | KP79_PYT06880 | A0A210QB18 | A0A210QUN1 | Tyrosine--tRNA ligase. | Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. | 0.772 |
KP79_PYT07321 | KP79_PYT08117 | A0A210QB18 | A0A210QBT4 | Tyrosine--tRNA ligase. | tRNA threonylcarbamoyladenosine biosynthesis protein YwlC. | 0.700 |
KP79_PYT07321 | KP79_PYT09716 | A0A210QB18 | A0A210QCL0 | Tyrosine--tRNA ligase. | Bifunctional glutamate/proline--tRNA ligase. | 0.999 |
KP79_PYT07321 | KP79_PYT17872 | A0A210QB18 | A0A210PIR9 | Tyrosine--tRNA ligase. | tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family. | 0.512 |
KP79_PYT07321 | KP79_PYT22900 | A0A210QB18 | A0A210QLL5 | Tyrosine--tRNA ligase. | Methionyl-tRNA formyltransferase, mitochondrial. | 0.744 |
KP79_PYT08117 | KP79_PYT06880 | A0A210QBT4 | A0A210QUN1 | tRNA threonylcarbamoyladenosine biosynthesis protein YwlC. | Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. | 0.743 |
KP79_PYT08117 | KP79_PYT07321 | A0A210QBT4 | A0A210QB18 | tRNA threonylcarbamoyladenosine biosynthesis protein YwlC. | Tyrosine--tRNA ligase. | 0.700 |
KP79_PYT08117 | KP79_PYT09716 | A0A210QBT4 | A0A210QCL0 | tRNA threonylcarbamoyladenosine biosynthesis protein YwlC. | Bifunctional glutamate/proline--tRNA ligase. | 0.699 |
KP79_PYT08117 | KP79_PYT11817 | A0A210QBT4 | A0A210QHW5 | tRNA threonylcarbamoyladenosine biosynthesis protein YwlC. | TP53RK-binding protein; Belongs to the CGI121/TPRKB family. | 0.707 |
KP79_PYT08117 | KP79_PYT13372 | A0A210QBT4 | A0A210PWH0 | tRNA threonylcarbamoyladenosine biosynthesis protein YwlC. | TP53-regulating kinase. | 0.721 |
KP79_PYT08117 | KP79_PYT14261 | A0A210QBT4 | A0A210PN87 | tRNA threonylcarbamoyladenosine biosynthesis protein YwlC. | Probable tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. | 0.950 |
KP79_PYT08117 | KP79_PYT15370 | A0A210QBT4 | A0A210QZ91 | tRNA threonylcarbamoyladenosine biosynthesis protein YwlC. | tRNA modification GTPase GTPBP3, mitochondrial. | 0.709 |