STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RBR_08320Shikimate kinase. (169 aa)    
Predicted Functional Partners:
RBR_08550
3-dehydroquinate synthase.
 
 
 0.989
RBR_08560
3-phosphoshikimate 1-carboxyvinyltransferase.
 
 
 0.985
RBR_08580
Prephenate dehydratase.
  
 
 0.984
aroE
Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
 
 
 0.974
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
 
 
 0.867
RBR_12540
Acetyltransferases, including N-acetylases of ribosomal proteins.
    
  0.857
RBR_08310
Pyruvate kinase; Belongs to the pyruvate kinase family.
   
 
 0.836
RBR_08530
3-deoxy-D-arabinoheptulosonate-7-phosphate synthase.
  
 
 0.672
RBR_06330
Anthranilate synthase, component I.
 
  
 0.549
metG
methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
     
 0.515
Your Current Organism:
Ruminococcus bromii
NCBI taxonomy Id: 657321
Other names: R. bromii L2-63, Ruminococcus bromii L2-63, Ruminococcus bromii str. L2-63, Ruminococcus bromii strain L2-63
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