node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
RBR_05610 | RBR_10870 | RBR_05610 | RBR_10870 | Acetolactate synthase, large subunit. | Acetolactate synthase, small subunit. | 0.999 |
RBR_05610 | RBR_10880 | RBR_05610 | RBR_10880 | Acetolactate synthase, large subunit. | Acetolactate synthase, large subunit. | 0.901 |
RBR_05610 | RBR_12780 | RBR_05610 | RBR_12780 | Acetolactate synthase, large subunit. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.984 |
RBR_05610 | RBR_13580 | RBR_05610 | RBR_13580 | Acetolactate synthase, large subunit. | Isocitrate dehydrogenase (NADP); Belongs to the isocitrate and isopropylmalate dehydrogenases family. | 0.607 |
RBR_05610 | RBR_13590 | RBR_05610 | RBR_13590 | Acetolactate synthase, large subunit. | Aconitase. | 0.440 |
RBR_05610 | ilvC | RBR_05610 | RBR_10860 | Acetolactate synthase, large subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.998 |
RBR_05610 | ilvD | RBR_05610 | RBR_09320 | Acetolactate synthase, large subunit. | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 0.975 |
RBR_05610 | leuB | RBR_05610 | RBR_13250 | Acetolactate synthase, large subunit. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.986 |
RBR_05610 | leuC | RBR_05610 | RBR_05530 | Acetolactate synthase, large subunit. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.683 |
RBR_05610 | leuD | RBR_05610 | RBR_05540 | Acetolactate synthase, large subunit. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.804 |
RBR_10870 | RBR_05610 | RBR_10870 | RBR_05610 | Acetolactate synthase, small subunit. | Acetolactate synthase, large subunit. | 0.999 |
RBR_10870 | RBR_10880 | RBR_10870 | RBR_10880 | Acetolactate synthase, small subunit. | Acetolactate synthase, large subunit. | 0.999 |
RBR_10870 | RBR_12780 | RBR_10870 | RBR_12780 | Acetolactate synthase, small subunit. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.995 |
RBR_10870 | ilvC | RBR_10870 | RBR_10860 | Acetolactate synthase, small subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.999 |
RBR_10870 | ilvD | RBR_10870 | RBR_09320 | Acetolactate synthase, small subunit. | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 0.928 |
RBR_10870 | leuB | RBR_10870 | RBR_13250 | Acetolactate synthase, small subunit. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.985 |
RBR_10870 | leuC | RBR_10870 | RBR_05530 | Acetolactate synthase, small subunit. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.865 |
RBR_10870 | leuD | RBR_10870 | RBR_05540 | Acetolactate synthase, small subunit. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.893 |
RBR_10880 | RBR_05610 | RBR_10880 | RBR_05610 | Acetolactate synthase, large subunit. | Acetolactate synthase, large subunit. | 0.901 |
RBR_10880 | RBR_10870 | RBR_10880 | RBR_10870 | Acetolactate synthase, large subunit. | Acetolactate synthase, small subunit. | 0.999 |