STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RBR_16700Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. (256 aa)    
Predicted Functional Partners:
spoIIAB
Anti-sigma F factor; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
  
  
 0.864
RBR_18630
Stage IV sporulation protein A; ATPase. Has a role at an early stage in the morphogenesis of the spore coat.
  
   
 0.862
RBR_15080
RNA polymerase, sigma 29 subunit, SigE; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
  
   
 0.847
RBR_02360
Transcriptional regulator, AbrB family.
  
   
 0.846
RBR_07690
Stage V sporulation protein AD (SpoVAD).
  
   
 0.844
RBR_18140
Uncharacterized protein conserved in bacteria.
 
   
 0.822
RBR_14900
Stage II sporulation protein R.
  
   
 0.818
RBR_12960
RNA polymerase, sigma 27/28 subunit, RpsK/SigK; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
  
  
 0.814
RBR_03780
Stage II sporulation protein E (SpoIIE).
  
  
 0.812
RBR_18110
Stage III sporulation protein AC/AD protein family.
 
   
 0.781
Your Current Organism:
Ruminococcus bromii
NCBI taxonomy Id: 657321
Other names: R. bromii L2-63, Ruminococcus bromii L2-63, Ruminococcus bromii str. L2-63, Ruminococcus bromii strain L2-63
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.