node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SEH62278.1 | SEH79317.1 | SAMN04488075_0419 | SAMN04488075_1088 | Ribonucleoside-triphosphate reductase class III catalytic subunit. | dCTP deaminase. | 0.772 |
SEH62278.1 | SEI03314.1 | SAMN04488075_0419 | SAMN04488075_2318 | Ribonucleoside-triphosphate reductase class III catalytic subunit. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.818 |
SEH62278.1 | ndk | SAMN04488075_0419 | SAMN04488075_0543 | Ribonucleoside-triphosphate reductase class III catalytic subunit. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.803 |
SEH62278.1 | tmk | SAMN04488075_0419 | SAMN04488075_1564 | Ribonucleoside-triphosphate reductase class III catalytic subunit. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.534 |
SEH64917.1 | SEI03304.1 | SAMN04488075_0574 | SAMN04488075_2317 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Molybdopterin or thiamine biosynthesis adenylyltransferase. | 0.572 |
SEH64917.1 | SEI03314.1 | SAMN04488075_0574 | SAMN04488075_2318 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.857 |
SEH64917.1 | SEI10374.1 | SAMN04488075_0574 | SAMN04488075_2896 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Ribonucleoside-diphosphate reductase class II; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | 0.666 |
SEH65497.1 | SEI03304.1 | SAMN04488075_0605 | SAMN04488075_2317 | Phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase. | Molybdopterin or thiamine biosynthesis adenylyltransferase. | 0.404 |
SEH65497.1 | SEI03314.1 | SAMN04488075_0605 | SAMN04488075_2318 | Phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.944 |
SEH65497.1 | SEI10320.1 | SAMN04488075_0605 | SAMN04488075_2891 | Phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase. | Deoxycytidylate deaminase. | 0.533 |
SEH65497.1 | tmk | SAMN04488075_0605 | SAMN04488075_1564 | Phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.570 |
SEH79317.1 | SEH62278.1 | SAMN04488075_1088 | SAMN04488075_0419 | dCTP deaminase. | Ribonucleoside-triphosphate reductase class III catalytic subunit. | 0.772 |
SEH79317.1 | SEI03314.1 | SAMN04488075_1088 | SAMN04488075_2318 | dCTP deaminase. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.926 |
SEH79317.1 | SEI10320.1 | SAMN04488075_1088 | SAMN04488075_2891 | dCTP deaminase. | Deoxycytidylate deaminase. | 0.534 |
SEH79317.1 | ndk | SAMN04488075_1088 | SAMN04488075_0543 | dCTP deaminase. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.929 |
SEH79317.1 | thyX | SAMN04488075_1088 | SAMN04488075_2455 | dCTP deaminase. | Thymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.586 |
SEH79317.1 | tmk | SAMN04488075_1088 | SAMN04488075_1564 | dCTP deaminase. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.625 |
SEI03304.1 | SEH64917.1 | SAMN04488075_2317 | SAMN04488075_0574 | Molybdopterin or thiamine biosynthesis adenylyltransferase. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.572 |
SEI03304.1 | SEH65497.1 | SAMN04488075_2317 | SAMN04488075_0605 | Molybdopterin or thiamine biosynthesis adenylyltransferase. | Phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase. | 0.404 |
SEI03304.1 | SEI03314.1 | SAMN04488075_2317 | SAMN04488075_2318 | Molybdopterin or thiamine biosynthesis adenylyltransferase. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.829 |