STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EGN40859.1Acetolactate synthase, large subunit, biosynthetic type. (562 aa)    
Predicted Functional Partners:
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.996
EGN40169.1
Acetolactate synthase, small subunit.
 
 0.996
EGN40721.1
Acetolactate synthase, small subunit.
 
 0.994
EGN40722.1
Acetolactate synthase, small subunit.
 
 0.994
EGN43485.1
Pyruvate:ferredoxin (flavodoxin) oxidoreductase.
  
 
 0.982
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
 
 0.982
ilvD
Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family.
 
 0.970
EGN46609.1
Threonine ammonia-lyase.
 
 0.947
EGN31514.1
Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family.
 
 0.938
EGN33746.1
Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family.
 
 0.935
Your Current Organism:
Lachnospiraceae bacterium 3157FAACT1
NCBI taxonomy Id: 658086
Other names: L. bacterium 3_1_57FAA_CT1, Lachnospiraceae bacterium 3_1_57FAA_CT1
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