node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EGN31884.1 | EPC05112.1 | HMPREF0994_05808 | HMPREF0994_07261 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Belongs to the HisA/HisF family. | Histidinol-phosphate transaminase. | 0.867 |
EGN31884.1 | hisB | HMPREF0994_05808 | HMPREF0994_02788 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Belongs to the HisA/HisF family. | Imidazoleglycerol-phosphate dehydratase. | 0.983 |
EGN31884.1 | hisC | HMPREF0994_05808 | HMPREF0994_04587 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Belongs to the HisA/HisF family. | Histidinol-phosphate transaminase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.883 |
EGN31884.1 | hisD | HMPREF0994_05808 | HMPREF0994_02787 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Belongs to the HisA/HisF family. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.990 |
EGN31884.1 | hisF | HMPREF0994_05808 | HMPREF0994_06746 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Belongs to the HisA/HisF family. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.998 |
EGN31884.1 | hisG | HMPREF0994_05808 | HMPREF0994_02786 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Belongs to the HisA/HisF family. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.990 |
EGN31884.1 | hisH | HMPREF0994_05808 | HMPREF0994_06747 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Belongs to the HisA/HisF family. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.998 |
EGN31884.1 | hisI | HMPREF0994_05808 | HMPREF0994_02789 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Belongs to the HisA/HisF family. | phosphoribosyl-ATP diphosphatase; In the C-terminal section; belongs to the PRA-PH family. | 0.999 |
EGN31884.1 | hisZ | HMPREF0994_05808 | HMPREF0994_02785 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Belongs to the HisA/HisF family. | ATP phosphoribosyltransferase, regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.969 |
EGN40250.1 | EPC05112.1 | HMPREF0994_03073 | HMPREF0994_07261 | HisJ family histidinol phosphate phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. | Histidinol-phosphate transaminase. | 0.696 |
EGN40250.1 | hisB | HMPREF0994_03073 | HMPREF0994_02788 | HisJ family histidinol phosphate phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. | Imidazoleglycerol-phosphate dehydratase. | 0.938 |
EGN40250.1 | hisC | HMPREF0994_03073 | HMPREF0994_04587 | HisJ family histidinol phosphate phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. | Histidinol-phosphate transaminase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.922 |
EGN40250.1 | hisD | HMPREF0994_03073 | HMPREF0994_02787 | HisJ family histidinol phosphate phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.962 |
EGN40250.1 | hisF | HMPREF0994_03073 | HMPREF0994_06746 | HisJ family histidinol phosphate phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.439 |
EGN40250.1 | hisG | HMPREF0994_03073 | HMPREF0994_02786 | HisJ family histidinol phosphate phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.506 |
EGN40250.1 | hisH | HMPREF0994_03073 | HMPREF0994_06747 | HisJ family histidinol phosphate phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.706 |
EGN40250.1 | hisI | HMPREF0994_03073 | HMPREF0994_02789 | HisJ family histidinol phosphate phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. | phosphoribosyl-ATP diphosphatase; In the C-terminal section; belongs to the PRA-PH family. | 0.905 |
EPC05112.1 | EGN31884.1 | HMPREF0994_07261 | HMPREF0994_05808 | Histidinol-phosphate transaminase. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Belongs to the HisA/HisF family. | 0.867 |
EPC05112.1 | EGN40250.1 | HMPREF0994_07261 | HMPREF0994_03073 | Histidinol-phosphate transaminase. | HisJ family histidinol phosphate phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. | 0.696 |
EPC05112.1 | hisB | HMPREF0994_07261 | HMPREF0994_02788 | Histidinol-phosphate transaminase. | Imidazoleglycerol-phosphate dehydratase. | 0.990 |