node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EGN40031.1 | EGN40032.1 | HMPREF0994_03201 | HMPREF0994_03202 | L-serine dehydratase, iron-sulfur-dependent, alpha subunit. | L-serine dehydratase, iron-sulfur-dependent, beta subunit. | 0.999 |
EGN40031.1 | EGN40940.2 | HMPREF0994_03201 | HMPREF0994_02541 | L-serine dehydratase, iron-sulfur-dependent, alpha subunit. | Hypothetical protein. | 0.822 |
EGN40031.1 | EGN43227.1 | HMPREF0994_03201 | HMPREF0994_00918 | L-serine dehydratase, iron-sulfur-dependent, alpha subunit. | Homoserine dehydrogenase. | 0.925 |
EGN40031.1 | EGN46609.1 | HMPREF0994_03201 | HMPREF0994_06685 | L-serine dehydratase, iron-sulfur-dependent, alpha subunit. | Threonine ammonia-lyase. | 0.943 |
EGN40031.1 | EGN47496.1 | HMPREF0994_03201 | HMPREF0994_06485 | L-serine dehydratase, iron-sulfur-dependent, alpha subunit. | Lactoylglutathione lyase. | 0.913 |
EGN40031.1 | glyA | HMPREF0994_03201 | HMPREF0994_00921 | L-serine dehydratase, iron-sulfur-dependent, alpha subunit. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.977 |
EGN40031.1 | metAA | HMPREF0994_03201 | HMPREF0994_02599 | L-serine dehydratase, iron-sulfur-dependent, alpha subunit. | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. | 0.918 |
EGN40031.1 | phnW | HMPREF0994_03201 | HMPREF0994_05042 | L-serine dehydratase, iron-sulfur-dependent, alpha subunit. | 2-aminoethylphosphonate-pyruvate transaminase; Involved in phosphonate degradation; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily. | 0.834 |
EGN40031.1 | trpA | HMPREF0994_03201 | HMPREF0994_06695 | L-serine dehydratase, iron-sulfur-dependent, alpha subunit. | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.918 |
EGN40031.1 | trpC | HMPREF0994_03201 | HMPREF0994_06698 | L-serine dehydratase, iron-sulfur-dependent, alpha subunit. | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. | 0.830 |
EGN40032.1 | EGN40031.1 | HMPREF0994_03202 | HMPREF0994_03201 | L-serine dehydratase, iron-sulfur-dependent, beta subunit. | L-serine dehydratase, iron-sulfur-dependent, alpha subunit. | 0.999 |
EGN40032.1 | EGN40940.2 | HMPREF0994_03202 | HMPREF0994_02541 | L-serine dehydratase, iron-sulfur-dependent, beta subunit. | Hypothetical protein. | 0.821 |
EGN40032.1 | EGN43227.1 | HMPREF0994_03202 | HMPREF0994_00918 | L-serine dehydratase, iron-sulfur-dependent, beta subunit. | Homoserine dehydrogenase. | 0.925 |
EGN40032.1 | EGN46609.1 | HMPREF0994_03202 | HMPREF0994_06685 | L-serine dehydratase, iron-sulfur-dependent, beta subunit. | Threonine ammonia-lyase. | 0.943 |
EGN40032.1 | EGN47496.1 | HMPREF0994_03202 | HMPREF0994_06485 | L-serine dehydratase, iron-sulfur-dependent, beta subunit. | Lactoylglutathione lyase. | 0.913 |
EGN40032.1 | glyA | HMPREF0994_03202 | HMPREF0994_00921 | L-serine dehydratase, iron-sulfur-dependent, beta subunit. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.978 |
EGN40032.1 | metAA | HMPREF0994_03202 | HMPREF0994_02599 | L-serine dehydratase, iron-sulfur-dependent, beta subunit. | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. | 0.918 |
EGN40032.1 | phnW | HMPREF0994_03202 | HMPREF0994_05042 | L-serine dehydratase, iron-sulfur-dependent, beta subunit. | 2-aminoethylphosphonate-pyruvate transaminase; Involved in phosphonate degradation; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily. | 0.834 |
EGN40032.1 | trpA | HMPREF0994_03202 | HMPREF0994_06695 | L-serine dehydratase, iron-sulfur-dependent, beta subunit. | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.918 |
EGN40032.1 | trpC | HMPREF0994_03202 | HMPREF0994_06698 | L-serine dehydratase, iron-sulfur-dependent, beta subunit. | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. | 0.830 |