STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SHI15012.1Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (577 aa)    
Predicted Functional Partners:
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.959
ilvE
Branched chain amino acid aminotransferase apoenzyme; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
  
 0.928
SHI15027.1
Regulator of RNase E activity RraA.
 
     0.880
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
  
 
 0.853
SHH68655.1
Glutamate synthase (NADH) large subunit.
  
  
 0.841
SHH72109.1
Acetolactate synthase, large subunit.
 
 0.833
SHI16829.1
Acetolactate synthase, large subunit.
 
 0.825
SHH44279.1
D-alanine transaminase.
  
 0.801
SHH92987.1
4-amino-4-deoxychorismate lyase.
  
 0.801
SHI20914.1
Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family.
 
 0.799
Your Current Organism:
Candidimonas bauzanensis
NCBI taxonomy Id: 658167
Other names: Alcaligenaceae bacterium BZ59, C. bauzanensis, CGMCC 1.10190, Candidimonas bauzanensis Zhang et al. 2012, DSM 22805, LMG 26046, LMG:26046, strain BZ59
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